NA methylation has bewildered molecular biologists since Hotchkiss discovered it almost six decades ago (Hotchkiss RDJ. Biol Cem 1948; 175:315-332). The fact that the chemical structure of our D genome consists of two components that are covalently bound, the genetic information that is replicated by the DNA replication machinery ana DNA methylation that is maintainea by independent enzymatic machinery, has redictably stimulated the imagination and curiosity of generations of mo� Edular biologists. An obvious question was whether DNA methylation was a bearer of additional information to the genetic information and what was the nature of this information? It was tempting to speculate that DNA me� thylation applied some form of control over programming of the genome s expression profile. Once techniques to probe the methylation profile of whole genomes as well as specific genes became available, it became clear that DNA methylation patterns are gene and tissue specific and that patterns of gene expression correlate with patterns of methylation. DNA methylation pat� terns emerged as the only component of the chemical structure of DNA that exhibited tissue and cell specificity. This data seemingly provided an attrac� tively simple explanation for the longstanding dilemma of how could one identical genome manifest itself in so many different forms in multicellular organisms? The DNA methylation pattern has thus become the only known factor to confer upon DNA a unique cellular identity.

"About this title" may belong to another edition of this title.

Store Description

Integrity Books & Music (IBM) carries thousands of out-of-print and hard-to-find books, and more at deep discount prices. We offer lightning fast shipping. Some 99% of our orders are shipped the same day they are received. Every item listed in our online store is housed in a single location which makes it possible for us to pack and ship most orders within an hour after it is received. Experience the IBM difference by placing your order today! We'll have it out the door in no time flat. (Although it might take the USPS a few days to do their part!) We employ highly skilled procurement specialists as professional treasure hunters who search the planet for the books customers are looking for. Let us know what you're looking for and see for yourself that, when it comes to finding great books, we got game!

Visit Seller's Storefront

Seller's business information

Integrity Books & Music
OH, U.S.A.

Sale & Shipping Terms

Terms of Sale

We guarantee the condition of every book as it's described on the Abebooks web sites. If you're
dissatisfied with your purchase (Incorrect Book/Not as Described/Damaged) or if the order hasn't
arrived,
you're eligible for a refund within 30 days of the estimated delivery date. If you've changed your mind
about a book that you've ordered, please use the Ask bookseller a question link to contact us and
we'll
respond within 2 business days.

Shipping Terms

Orders usually ship within 24 hours. Shipping costs are based on books weighing 2.2 LB, or 1 KG. If your book order is heavy or oversized, you can calculate the cost of shipping via USPS Media Mail at approx. .50 cents per additional pound. All orders are professionally packed in high-quality, water-resistant bubble mailers and/or boxes specially made for certain and more valuable items. FREE Delivery Confirmation service is included with all orders shipped via USPS.

Shipping rates within U.S.A.

Shipping rates within U.S.A.
Order quantity	3 to 10 business days	2 to 5 business days
First item	US$ 8.79	US$ 12.95

Delivery times are set by sellers and vary by carrier and location. Orders passing through Customs may face delays and buyers are responsible for any associated duties or fees. Sellers may contact you regarding additional charges to cover any increased costs to ship your items.