Delayed Preconditioning and Adaptive Cardioprotection

Interest in the ability of myocardium to adapt to ischaemic stress has continued to grow since the discovery of ischaemic preconditioning in 1986. In 1993, two reports heralded the recognition of a delayed preconditioning response in the heart, now commonly known as the `second window' of protection. Since then, a number of studies have described the ability of delayed preconditioning and related adaptive phenomena to protect against a variety of pathologies in the ischaemic and reperfused myocardium. Our understanding of the cellular mechanisms of sub-acute adaptive cardioprotection has advanced considerably during this period. This compilation of state-of-the-art reviews by those who have made significant contributions to this field provides detailed and critical analysis of this research, from molecular basis to potential clinical relevance. The book aims to provide an authoritative, comprehensive and thoroughly up-to-date overview for scientists and clinicians engaged in, or observing, this rapidly-developing area of heart research. It will also be of interest to those engaged in research on other tissues where ischaemia-reperfusion pathology is of major concern.

`This book is recommended for physiologists, cardiologists, and cardiac surgeons vaguely aware of the concept, who want to know more about it.'
Acta cardiologica, 54:3 (1999)
`... this up-to-date review of literature is timely... the editors have done a commendable job of assembling well known experts...to compile this essential review of delayed preconditioning research.'
The Bulletin, 13:2 (2000)