Design and Development of Carvedilol Phosphate Floating Microsphere: Formulation and in-vitro Evalution of Carvedilol Phosphate Floating Microsphere

Joshi, Pranav, Patel, Mukesh, Patel, Natavarlal

ISBN 10: 3659407631 / ISBN 13: 9783659407635

Published by LAP LAMBERT Academic Publishing, 2013

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Bibliographic Details

• Title: Design and Development of Carvedilol Phosphate Floating Microsphere: Formulation and in-vitro Evalution of Carvedilol Phosphate Floating Microsphere
• Publisher: LAP LAMBERT Academic Publishing
• Publication Date: 2013
• Language: English
• ISBN 10: 3659407631
• ISBN 13: 9783659407635
• Binding: Paperback
• Condition: Like New
• Book Type: book

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Synopsis

Carvedilol has unique pharmacological profile. It blocks β1, β2, and α1 receptors, used in the management of hypertension and as an adjunct to standard therapy in symptomatic heart failure and also produces vasodilation. In the present study, an attempt has been made to improve drug concentration in the stomach by preparing gastroretentive floating microsphere of carvedilol phosphate to maintain drug levels within a desired range, reduce dosing frequency, Improve patient compliance, improve dissolution and at the site of absorption.Drug molecules presenting no difficulties in their solubility and/or absorption problems are good candidates for oral controlled release formulations but Obstacle may arise for many drugs related to their solubility and/or absorption that may be overcome by formulating Gastroretentive systems which prolong the gastric retention time, improves solubility and hence improves bioavailability for drugs that are less soluble in a high pH environment.

About the Author

Mr. Pranav Joshi have completed B.Pharma from Rajiv Gandhi University of health sciences, Bangalore and awarded gold medal for being topper of college.He completed M.pharma from Gujarat Technological university, Ahmadabad, also he has published many research paper in international journals.