Design and Development of Extended Release Tablet of Nicotinic acid | The formulation deduction of drug flushing

Brijeshkumar Chaudhari (u. a.)

ISBN 10: 3659151882 / ISBN 13: 9783659151880

Published by LAP LAMBERT Academic Publishing, 2012

About this Item

Design and Development of Extended Release Tablet of Nicotinic acid | The formulation deduction of drug flushing | Brijeshkumar Chaudhari (u. a.) | Taschenbuch | 120 S. | Englisch | 2012 | LAP LAMBERT Academic Publishing | EAN 9783659151880 | Verantwortliche Person für die EU: BoD - Books on Demand, In de Tarpen 42, 22848 Norderstedt, info[at]bod[dot]de | Anbieter: preigu.

Seller Inventory # 106417966

Bibliographic Details

• Title: Design and Development of Extended Release Tablet of Nicotinic acid | The formulation deduction of drug flushing
• Publisher: LAP LAMBERT Academic Publishing
• Publication Date: 2012
• Language: English
• ISBN 10: 3659151882
• ISBN 13: 9783659151880
• Binding: Taschenbuch
• Condition: Neu
• Dimensions: 220W x 150H x 8D millimeters 220 millimeters width by 150 millimeters height by 8 millimeters depth
• Weight: 197 grams
• Seller catalogs:
  • Bücher

About this title

Synopsis

Nicotinic acid (NA) as lipid lowering agent drug has not become a first-line treatment due to the strong side effect called flushing occurs when given in immediate release dosage form. The tablets were prepared by wet granulation method using HPMC K-15M, polymer as retardant and the prepared tablets of NA will remain intact up to 2 hrs in pH 1.2 due to Eudragit L 100-55 and its release is not only initiated but tact fully retarded up to 12 hrs and were found to be superior in physical properties,dissolution characteristics, and drug content uniformity. The drug release from the matrix tablet Fitted to the Higuchi model and Zero order release which indicates non-Fickian diffusion.N8 showed good similarity with theoretical profile of nicotinic acid. Excipients has significant effect on drug release,because DCP retarded the release due to hydrophobic nature, on the contrary MCC increased drug release for its swelling property and causing burst release, and lactose moderately affected drug release due to channeling action and hence causing drug release at desired rate and amount. The studies indicate that the formulation was effective in providing in vitro release for extended period.

About the Author

Mr. Brijeshkumar Chaudhari has obtained M. Pharm Degree in Pharmaceutics specialization in 2012. He is the author with several articles published in journals.