Design and Optimization in Organic Synthesis (Data Handling in Science and Technology, Volume 8)

Carlson, R.

ISBN 10: 044489201X / ISBN 13: 9780444892010

Published by Elsevier Science Ltd, 2000

About this Item

4th impression. Light wear to boards with a lean. Content is clean and bright with light marks on the outer edge pages. No DJ.

Seller Inventory # 9999-9994054144

Bibliographic Details

• Title: Design and Optimization in Organic Synthesis (Data Handling in Science and Technology, Volume 8)
• Publisher: Elsevier Science Ltd
• Publication Date: 2000
• Language: English
• ISBN 10: 044489201X
• ISBN 13: 9780444892010
• Binding: Hardcover
• Edition: 3rd Edition
• Condition: Good

About this title

Synopsis

This is the first general textbook on experimental design and optimization in organic synthesis. The book presents a unified methodology for carrying out systematic studies when the objective is to develop efficient and optimum synthetic methods. Strategies are included both for exploring the experimental conditions and for systematic studies of entire reaction systems (substrates, reagent(s) and solvents). The methodology is based on multivariate statistical techniques.

The following topics are treated in depth: classical two-level designs for screening experiments, gradient methods (steepest ascent, simplex methods) as well as response surface techniques for optimization, principal components analysis and PLS modelling.

The book is intended as a hands-on text for chemists and engineers engaged in developing synthetic methods in industrial research, e.g. in fine chemicals and pharmaceuticals production, as well as for advanced undergraduate students, graduate students, and researchers in an academic environment.

Book Description

A revised and updated second edition to the only book on Design and Optimization in Organic Synthesis