Design and Synthesis of 1,4-Diazepines as Selective Cox-II Inhibitors

Chirag J. Patel

ISBN 10: 3659337862 / ISBN 13: 9783659337864

Published by LAP LAMBERT Academic Publishing, 2013

About this Item

Design and Synthesis of 1,4-Diazepines as Selective Cox-II Inhibitors | Chirag J. Patel | Taschenbuch | 68 S. | Englisch | 2013 | LAP LAMBERT Academic Publishing | EAN 9783659337864 | Verantwortliche Person für die EU: preigu GmbH & Co. KG, Lengericher Landstr. 19, 49078 Osnabrück, mail[at]preigu[dot]de | Anbieter: preigu.

Seller Inventory # 105595783

Bibliographic Details

• Title: Design and Synthesis of 1,4-Diazepines as Selective Cox-II Inhibitors
• Publisher: LAP LAMBERT Academic Publishing
• Publication Date: 2013
• Language: English
• ISBN 10: 3659337862
• ISBN 13: 9783659337864
• Binding: Taschenbuch
• Condition: Neu
• Dimensions: 220W x 150H x 5D millimeters 220 millimeters width by 150 millimeters height by 5 millimeters depth
• Weight: 119 grams
• Seller catalogs:
  • Bücher

About this title

Synopsis

The NSAIDs have known to cause serious problems such as gastric ulceration, bleeding and renal disorders on long term medication. These severe side effects are partially due to their nonselectivity towards to COX-2 enzyme. Hence, newer, selective COX-2 enzyme inhibitors have been developed to overcome the toxicity problems. Recently, Rofecoxib and Celecoxib were withdrawn due to cardiac toxicity.1,2-disubstituted five-membered heterocyclic compounds have shown selectivity towards COX-2 inhibition. But, the toxicity reports of drugs like Rofecoxib and Celecoxib in this category prompted us to synthesize 1,2-diaryl diazepines (E) and their derivatives as, survey of literature indicated the diazepine heterocyclic system to have anti-inflammatory activity.

About the Author

Prof. Chirag J. Patel, Ph.D. fellow in Pharmaceutical Sciences at K.S.K.V. Kachchh University, Bhuj-Kachchh, Gujarat, INDIA. Field of Study: Phytopharmacoligal Screening of Some Laticiferous Plants & Drug Design with Development. Presently working as an Associate Professor at Veerayatan Institute of Pharmacy, India from last seven years.