Design, Synthesis, QSAR Studies of some DPP-IV Inhibitors | Design, Synthesis, QSAR studies and Biological evaluation of Novel Triazolopiperazine Based DPP-IV Inhibitors

Ketaki Dhane

ISBN 10: 6204211420 / ISBN 13: 9786204211428

Published by LAP LAMBERT Academic Publishing, 2021

About this Item

Design, Synthesis, QSAR Studies of some DPP-IV Inhibitors | Design, Synthesis, QSAR studies and Biological evaluation of Novel Triazolopiperazine Based DPP-IV Inhibitors | Ketaki Dhane | Taschenbuch | Englisch | 2021 | LAP LAMBERT Academic Publishing | EAN 9786204211428 | Verantwortliche Person für die EU: preigu GmbH & Co. KG, Lengericher Landstr. 19, 49078 Osnabrück, mail[at]preigu[dot]de | Anbieter: preigu.

Seller Inventory # 120806187

Bibliographic Details

• Title: Design, Synthesis, QSAR Studies of some DPP-IV Inhibitors | Design, Synthesis, QSAR studies and Biological evaluation of Novel Triazolopiperazine Based DPP-IV Inhibitors
• Publisher: LAP LAMBERT Academic Publishing
• Publication Date: 2021
• Language: English
• ISBN 10: 6204211420
• ISBN 13: 9786204211428
• Binding: Taschenbuch
• Condition: Neu
• Dimensions: 220W x 150H x 8D millimeters 220 millimeters width by 150 millimeters height by 8 millimeters depth
• Weight: 197 grams
• Seller catalogs:
  • Bücher

About this title

Synopsis

Diabetes mellitus (DM) is one of the most common chronic disorder with increasing prevalence worldwide. Different classes of oral anti-hyperglycemic agents with nearly equipotent efficacy are now available; however, almost all of them are associated with one or more adverse effects. The new approaches in management of type 2 DM (T2DM) are based upon the effects of incretin hormones; Glucagon-Like Peptide-1 (GLP-1), Glucose-dependent insulinotropic peptide (GIP) and dipeptidyl peptidase (DPP-IV) inhibitors, which act via enhancing the incretin secretion. QSAR is the computer-based mathematical model which establishes a correlation between structure and its biological activity. In present studies, QSAR of one of the reported triazolopiperazine based β-aminoamides have been studied. In present studies, an attempt was made to synthesize the novel and selective 3-amino-1-(8- (cyclopropyl(3-mercapto-4H-1,2,4-triazol-4-ylamino)methyl)-2-(trifluoromtrifluromethyl)-5,6,7,8-tetrahydro-imidazolo(4,5a)-piperidine.The details of the regressional analysis, QSAR, rationale behind design, synthesis, structural characterisation and DPP- IV enzyme inhibitory activity are presented.