Detection of Anti malarial IgG/IgG subclasses in sudanies patients

Mona Mohamed El. Toum El. Sheisk

ISBN 10: 384338178X / ISBN 13: 9783843381789

Published by LAP LAMBERT Academic Publishing Mär 2011, 2011

About this Item

Neuware -Merozoite surface protein MSP2 is avaccine candidate antigen of Plasmodium falciparum that is polymorphic in natural populations. In this study we aimed to investigate whether malaria infection in associated with anti-malaria specific IgG, using recombinant proteins derived from the two major allelic types of MSP2 and ABO blood group. The conclusion is the Higher anti-malarial IgG1, IgG3, IgG2 and lower levels of IgG4 were associated with reduced risk of malaria infection. IgG2 is activator of the classical complement pathway, Fc¿RIIa H131 is essential for handling IgG2 immune complexes. These data suggest that an MSP2 based vaccine should be designed to induce high level antibody responses against the different MSP2 types present globally in P. falciparum populations and that MSP2 could be combined with other P. falciparum antigens to form a multi-component malaria vaccine.Books on Demand GmbH, Überseering 33, 22297 Hamburg 68 pp. Englisch.

Seller Inventory # 9783843381789

Bibliographic Details

• Title: Detection of Anti malarial IgG/IgG subclasses in sudanies patients
• Publisher: LAP LAMBERT Academic Publishing Mär 2011
• Publication Date: 2011
• Language: English
• ISBN 10: 384338178X
• ISBN 13: 9783843381789
• Binding: Taschenbuch
• Condition: Neu
• Dimensions: 220W x 150H x 5D millimeters 220 millimeters width by 150 millimeters height by 5 millimeters depth
• Weight: 119 grams

About this title

Synopsis

Merozoite surface protein MSP2 is avaccine candidate antigen of Plasmodium falciparum that is polymorphic in natural populations. In this study we aimed to investigate whether malaria infection in associated with anti-malaria specific IgG, using recombinant proteins derived from the two major allelic types of MSP2 and ABO blood group. The conclusion is the Higher anti-malarial IgG1, IgG3, IgG2 and lower levels of IgG4 were associated with reduced risk of malaria infection. IgG2 is activator of the classical complement pathway, Fc?RIIa H131 is essential for handling IgG2 immune complexes. These data suggest that an MSP2 based vaccine should be designed to induce high level antibody responses against the different MSP2 types present globally in P. falciparum populations and that MSP2 could be combined with other P. falciparum antigens to form a multi-component malaria vaccine.

About the Author

(Say that my prayer and my sacrifice and my life and my death to Allah, Lord of the Worlds) To my parents,family,friends and every one believed on me and who participated in giving birth to this work.