Determination of Some Drugs by Oxidative Coupling Method

Fadhel, Sahar, Abdulla, Najwa, Sulaiman, Intidhar

ISBN 10: 3330046805 / ISBN 13: 9783330046801

Published by LAP LAMBERT Academic Publishing, 2017

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Bibliographic Details

• Title: Determination of Some Drugs by Oxidative Coupling Method
• Publisher: LAP LAMBERT Academic Publishing
• Publication Date: 2017
• Language: English
• ISBN 10: 3330046805
• ISBN 13: 9783330046801
• Binding: paperback
• Condition: New
• Book Type: book

About this title

Synopsis

Three drugs are reacted with 2,4-dinitrophenyl hydrazine (2,4-DNPHz) in the presence of potassium periodate and sodium hydroxide to form colored products. The absorbance values for the formed complexes were measured at 403nm for olanzapine, 405nm for trifluoperazine hydrochloride, and 485nm for carbamazepine; against reagent blank. Different variables affecting the completion of the reaction have been carefully optimized by varying the parameters one at a time and controlling all others fixed. The results show better optical characteristics for calibration curve and statistical data under optimum conditions.

About the Author

Dr. Sahar R. Fadhel, Department of Chemistry, College of Science, University of Diyala, Iraq.Ass. Prof. Dr. Najwa I. Abdulla and Ass. Prof. Dr. Intidhar D. Sulaiman, Deptartment of Chemistry at Ibn Al-Haitham Education for Pure Science, University of Baghdad, Iraq.