Developing Novel Biointerfaces and Biomaterials with SPR/SPR Imaging | Expanding the Limits of SPR Spectroscopy and SPR Imaging

Matthew Linman (u. a.)

ISBN 10: 3847321889 / ISBN 13: 9783847321880

Published by LAP LAMBERT Academic Publishing, 2012

About this Item

Developing Novel Biointerfaces and Biomaterials with SPR/SPR Imaging | Expanding the Limits of SPR Spectroscopy and SPR Imaging | Matthew Linman (u. a.) | Taschenbuch | 300 S. | Englisch | 2012 | LAP LAMBERT Academic Publishing | EAN 9783847321880 | Verantwortliche Person für die EU: BoD - Books on Demand, In de Tarpen 42, 22848 Norderstedt, info[at]bod[dot]de | Anbieter: preigu.

Seller Inventory # 106644218

Bibliographic Details

• Title: Developing Novel Biointerfaces and Biomaterials with SPR/SPR Imaging | Expanding the Limits of SPR Spectroscopy and SPR Imaging
• Publisher: LAP LAMBERT Academic Publishing
• Publication Date: 2012
• Language: English
• ISBN 10: 3847321889
• ISBN 13: 9783847321880
• Binding: Taschenbuch
• Condition: Neu
• Dimensions: 220W x 150H x 18D millimeters 220 millimeters width by 150 millimeters height by 18 millimeters depth
• Weight: 465 grams
• Seller catalogs:
  • Bücher

About this title

Synopsis

Much research has focused on the development of analytical methods to monitor a multitude of biological interactions including protein-carbohydrate and protein-lipid among others. Surface plasmon resonance (SPR) remains one of the most exciting techniques that allows for real-time data collection and label free detection amenable to many biological systems. This thesis focuses on the development of novel sensing interfaces/materials for biomolecular interaction analysis (BIA) with SPR and SPR imaging (SPRi). The first portion of this work focuses on the development of unique surface chemistry designs to examine biological interactions including the development of a high-density array to detect carbohydrate-lectin interactions with SPRi. The second part of this thesis focuses on the development of new substrates for both SPR and SPR imaging experiments. The fabrication of a nanometric thick layer of glass-on-gold to detect protein-lipid interactions with SPR is presented. Finally, the facile fabrication of gold-coated etched glass substrates for SPR imaging that reduces background resonance 5-fold in situ compared to the standard gold island array platform is presented as well.

About the Author

Matthew Linman, Ph.D. is currently an Engineering Scientist at Meso Scale Diagnostics in Maryland, USA. He received his Ph.D. in analytical chemistry from the University of California-Riverside in 2011 and his bachelors from the College of Wooster in 2005. He is an author on nearly 20 scientific publications including 2 book chapters.