Development of Colon Targetted Produg of Etodolac

Language: English

Published by LAP LAMBERT Academic Publishing Sep 2021, 2021

6200224439 / 9786200224439

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This item is printed on demand - Print on Demand Titel. Neuware -In the present study carboxylic group of Etodolac, responsible for gastric side effects, was masked temporarily not only to overcome the side effects but also to achieve colon specific delivery. Amide prodrug (Etodolac-glycine conjugate) was synthesized by coupling Etodolac with glycine The synthesized prodrug was characterized by melting point, thin layer chromatography, RM values, scanning electro microscopy, x-ray diffraction crystallography and High performance liquid chromatography. Aqueous solubilities and lipophilicity (log P) values were determined at different pH media namely HCl buffer pH 1.2, acid phthalate buffer pH 4.0, phosphate buffer pH 6.8 and pH 7.4. In vitro reversion of Etodolac-glycine conjugate to Etodolac was done at different pH including colonic environment. In vitro reversion, showed prodrug to remain intact in all the other tested pH except colonic pH, where the colonic microfloral enzymes (amidase) hydrolyzed Etodolac-glycine conjugate amide linkage, releasing the free drug.VDM Verlag, Dudweiler Landstraße 99, 66123 Saarbrücken 76 pp. Englisch.…

Seller Inventory # 9786200224439

Title
Development of Colon Targetted Produg of Etodolac
Author
Gaurav Tiwari
Publisher
LAP LAMBERT Academic Publishing Sep 2021
Publication year
2021
Condition
Neu
Binding
Taschenbuch
Language
English
ISBN 10
6200224439
ISBN 13
9786200224439
Item weight
131 grams
Dimensions
220x150x6 mm

buchversandmimpf2000

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