Development of Compression Coated Colon Targeted 5-Fluorouracil Tablet: Development and Characterization of Compression Coated Colon Targeted Tablet of 5-Fluorouracil

Patel, Mukesh, Patel, Kanu, Patel, Natvarlal

ISBN 10: 3659221945 / ISBN 13: 9783659221941

Published by LAP LAMBERT Academic Publishing, 2012

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Bibliographic Details

• Title: Development of Compression Coated Colon Targeted 5-Fluorouracil Tablet: Development and Characterization of Compression Coated Colon Targeted Tablet of 5-Fluorouracil
• Publisher: LAP LAMBERT Academic Publishing
• Publication Date: 2012
• Language: English
• ISBN 10: 3659221945
• ISBN 13: 9783659221941
• Binding: Paperback
• Condition: Like New
• Book Type: book

About this title

Synopsis

The purpose of this study was to develop and evaluate a drug delivery system in vitro based on a compression coated tablet containing 5-fluorouracil (5-FU) in core and pectin Hydroxypropyl Methylcellulose (HPMC) mixture in coat layer. The main reason for selecting pectin was its biodegradation in colon by colonic flora. On other hand, high molecular weight HPMC increases mechanical strength of tablet coat around a drug core during its transportation in gastro-intestinal tract. Multiple regression analysis with two way ANOVA revealed that both factors had statistically significant influence for the response studied (P<0.05). Results of Tukey test showed the relative contribution of each level of different factors for the response studied.

About the Author

DR. Mukesh R Patel did B.Pharm from N M University & M.Pharm From Rajiv Gandhi University and doctorate From H N G University, Gujarat, India.He started his carrier as a Lecturer and currently working as associate professor and HOD in Pharmaceutics at BMCPER, Modasa.He has Published number of Research Papers in National and International journals.