Development of Controlled Release Three-Layered Diclofenac Tablet

Arafat, Mohammad; Sultana, Farhana; Manirujjaman, -

ISBN 10: 3659462128 / ISBN 13: 9783659462122

Published by VDM Verlag Dr. Mueller Aktiengesellschaft & Co. KG, 2014

About this Item

Print on Demand pp. 76 2:B&W 6 x 9 in or 229 x 152 mm Perfect Bound on Creme w/Gloss Lam.

Seller Inventory # 132820698

Bibliographic Details

• Title: Development of Controlled Release Three-Layered Diclofenac Tablet
• Publisher: VDM Verlag Dr. Mueller Aktiengesellschaft & Co. KG
• Publication Date: 2014
• Language: English
• ISBN 10: 3659462128
• ISBN 13: 9783659462122
• Binding: Soft cover
• Condition: New

About this title

Synopsis

Modified release dosage forms offer definite advantages over conventional release formulation of the same drug.The three-layered matrix system overcomes inherent disadvantages of non-linearity associated with the core, covered by two additional layers, each with different rates of swelling, gelling and erosion, is what accounts for the rate of drug release. When the tablet is first swallowed, the drug concentration is high but the surface area is small. As time goes by and the core swells, the surface area expands to compensate for the decrease in drug concentration. Based on these theoretical considerations the three-layered tablets were designed and Diclofenac Sodium, a weakly acidic drug and widely used NSAID, was taken as the model drug to evaluate the comparative release characteristics from different polymer matrices with different amount with the variation in the outer layers as well as in the core.Then the percent release from different batches of Diclofenac Sodium was plotted against time to get the zero order plots. In the zero order plots no true straight lines were obtained but statistically significant differences were found among the release profile.

About the Author

Mohammad Arafat is a Swedish Institute scholar studying Master's in Biomedicine & Methods in Medical Diagnostics,Experimental Medicine, having a M.S. degree in Pharmaceutical Technology. He worked previously at BDPF of Incepta Pharma. Ltd. Farhana Sultana and Manirujjaman have completed their B.Pharm and M.Pharm degree and engaged in research work.