Development of Controlled Release Three-layered Diclofenac Tablet

Language: English

Published by LAP LAMBERT Academic Publishing, 2014

3659462128 / 9783659462122

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Seller: AHA-BUCH GmbH, Einbeck, GermanyAHA-BUCH GmbH

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nach der Bestellung gedruckt Neuware - Printed after ordering - Modified release dosage forms offer definite advantages over conventional release formulation of the same drug.The three-layered matrix system overcomes inherent disadvantages of non-linearity associated with the core, covered by two additional layers, each with different rates of swelling, gelling and erosion, is what accounts for the rate of drug release. When the tablet is first swallowed, the drug concentration is high but the surface area is small. As time goes by and the core swells, the surface area expands to compensate for the decrease in drug concentration. Based on these theoretical considerations the three-layered tablets were designed and Diclofenac Sodium, a weakly acidic drug and widely used NSAID, was taken as the model drug to evaluate the comparative release characteristics from different polymer matrices with different amount with the variation in the outer layers as well as in the core.Then the percent release from different batches of Diclofenac Sodium was plotted against time to get the zero order plots. In the zero order plots no true straight lines were obtained but statistically significant differences were found among the release profile.…

Seller Inventory # 9783659462122

Title
Development of Controlled Release Three-layered Diclofenac Tablet
Author
Manirujjaman
Publisher
LAP LAMBERT Academic Publishing
Publication year
2014
Condition
Neu
Binding
Taschenbuch
Language
English
ISBN 10
3659462128
ISBN 13
9783659462122
Item weight
131 grams
Dimensions
220x150x6 mm

AHA-BUCH GmbH

Einbeck, Germany

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