Development and Evaluation of Poorly Soluble Rilpivirine by Snedds

Language: English

Published by LAP LAMBERT Academic Publishing Okt 2020, 2020

6202667672 / 9786202667678

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This item is printed on demand - Print on Demand Titel. Neuware -In this work a SNEDDS formulation of a poorly water-soluble drug, Rilpivirine was developed by using different polymers. The solubility study was conducted to find out the suitable oil, surfactant and co-surfactant for Rilpivirine and was shown good solubility in oil like Captex 355, surfactant Kolliphor RH 40 and co-surfactant Propylene glycol. The drug content of all the formulations was performed. Maximum drug content was found in the formulation F5. The in vitro dissolution studies were performed for all the fifteen SNEDDS formulations. The release from liquid SNEDDS formulation F5 was faster than SNEDDS formulations F1 toF15 indicating the influence of droplet size on the rate of drug dissolution. On the basis of visual observation test and faster dissolution rate, formulation F5 was finalized as optimized formulation. The present exploratory work successfully illustrates the potential utility of liquid SNEDDS formulation for the delivery of poor water-soluble compound such as Rilpivirine. The results from this study demonstrate the utility of SNEDDS to enhance solubility and dissolution of Rilpivirine which may result in improved therapeutic performance.VDM Verlag, Dudweiler Landstraße 99, 66123 Saarbrücken 100 pp. Englisch.…

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Bibliographic details

Title
Development and Evaluation of Poorly Soluble Rilpivirine by Snedds
Author
Pamu Sandhya
Publisher
LAP LAMBERT Academic Publishing Okt 2020
Publication year
2020
Condition
Neu
Binding
Taschenbuch
Language
English
ISBN 10
6202667672
ISBN 13
9786202667678
Item weight
167 grams
Dimensions
220x150x6 mm

buchversandmimpf2000

Emtmannsberg, BAYE, Germany

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