Development and Evaluation of Proliposomes-Based Drug Delivery Systems: Proliposomes-Based Drug Delivery Systems

Gupta, Sandeep, Ahirwar, Dheeraj, Pandey, Aditya Nath

ISBN 10: 3659160989 / ISBN 13: 9783659160981

Published by LAP LAMBERT Academic Publishing, 2012

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Seller Inventory # ERICA79636591609896

Bibliographic Details

• Title: Development and Evaluation of Proliposomes-Based Drug Delivery Systems: Proliposomes-Based Drug Delivery Systems
• Publisher: LAP LAMBERT Academic Publishing
• Publication Date: 2012
• Language: English
• ISBN 10: 3659160989
• ISBN 13: 9783659160981
• Binding: Paperback
• Condition: Like New
• Book Type: book

About this title

Synopsis

The present investigation aimed at formulation, and evaluation of vesicular drug carrier system liquid crystalline proliposomes for transdermal delivery of antifungal agent, griseofulvin. Liquid crystalline proliposomal gel (LCPG) formulations of griseofulvin were prepared, and characterized for vesicles shape, size, entrapment efficiency, and drug permeation across pig ear skin. The effects of different formulation variables (type of alcohol, type and concentration of surfactant) on transdermal permeability profile were assessed. The optimized LCPG formulation showed enhanced In Vitro skin permeation flux of 10.705 ± 0.052 µg/cm2/hr as compared to 0.028 ± 0.02 µg/cm2/hr for plain drug solution in water. Results indicated that the optimized proliposomal formulation of griseofulvin had better skin permeation potential than plain drug solution in water.

About the Author

(M. Pharm, Phd)School of Pharmacy, Chouksey Engineering College.