Development of Novel Indolyl-derived Biologically Active Compounds | Synthesis, Characterization and Applications as (Anti-MRSA, Anticancer)

Mardia El Sayed

ISBN 10: 3659320714 / ISBN 13: 9783659320712

Published by LAP LAMBERT Academic Publishing, 2015

About this Item

Development of Novel Indolyl-derived Biologically Active Compounds | Synthesis, Characterization and Applications as (Anti-MRSA, Anticancer) | Mardia El Sayed | Taschenbuch | 312 S. | Englisch | 2015 | LAP LAMBERT Academic Publishing | EAN 9783659320712 | Verantwortliche Person für die EU: preigu GmbH & Co. KG, Lengericher Landstr. 19, 49078 Osnabrück, mail[at]preigu[dot]de | Anbieter: preigu.

Seller Inventory # 104712119

Bibliographic Details

• Title: Development of Novel Indolyl-derived Biologically Active Compounds | Synthesis, Characterization and Applications as (Anti-MRSA, Anticancer)
• Publisher: LAP LAMBERT Academic Publishing
• Publication Date: 2015
• Language: English
• ISBN 10: 3659320714
• ISBN 13: 9783659320712
• Binding: Taschenbuch
• Condition: Neu
• Dimensions: 220W x 150H x 20D millimeters 220 millimeters width by 150 millimeters height by 20 millimeters depth
• Weight: 483 grams
• Seller catalogs:
  • Bücher

About this title

Synopsis

MRSA is a methicillin-resistance Staphylococcus aureus and a strain of Staphylococcus aureus that developed resistance to the killing effect of the β-lactam antibiotics, which include the penicillins (methicillin, dicloxacillin, oxacillin, etc.), MRSA is sometimes called a “superbug” because it is very difficult to treat and it causes a huge number of infections every year in hospitals all over the world. The novel synthesized indoles will add a valuable new addition to the antibacterial arsenal for MRSA infections, it would be new bactericidal agents effective against resistant isolates or standard. We have shown for the first time that the cycloalkanoindoles,bis-indolobenzocarbazoles and the oxidized bis-indolylmethenes inhibited growth of drug resistant MRSA either standard or isolate and other Gram-positive bacteria at low concentrations. Some of these novel bis- and tris-indolyl compounds described in this work have been screened in the national cancer institute (NCI) in USA for one and five dose that showed the highest antipoliferative activity in a nanomolar scale towards the selected cancers cell lines (Non small lung: NCIeH460, Ovarian: OVCAR-4 and Breast: MCF).