Development of Osmotically Controlled Drug Delivery System: Development and In-Vitro evaluation of Elementary Osmotic Pump (Tablet) of Etoricoxib

Shekh, Tabasubano, Bhople, Amit, Jaiswal, Sunil

ISBN 10: 3659370517 / ISBN 13: 9783659370519

Published by LAP LAMBERT Academic Publishing, 2013

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Bibliographic Details

• Title: Development of Osmotically Controlled Drug Delivery System: Development and In-Vitro evaluation of Elementary Osmotic Pump (Tablet) of Etoricoxib
• Publisher: LAP LAMBERT Academic Publishing
• Publication Date: 2013
• Language: English
• ISBN 10: 3659370517
• ISBN 13: 9783659370519
• Binding: Paperback
• Condition: Like New
• Book Type: book

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Synopsis

Etoricoxib is non steroidal anti-inflammatory drug specifically Cyclooxygenase 2 (COX-2) enzyme inhibitor. Etoricoxib have serious side effect like gastric disturbance, gastric ulceration, gastrointestinal (GIT) bleeding. Conventional drug delivery systems do not have much control over the drug release and effective concentration of drug reach at the target site. It may lead to unsteady plasma drug level result into adverse effect due to plasma drug level crossing therapeutic window and undertherparutic response because of plasma drug level below therapeutic window. GIT side effect of Etoricoxib due to unsteady plasma drug level when administered in conventional dosage form. Development of elementary osmotic pump for etoricoxib release the drug in controlled fashion by zero order result in mentainance of constant plasma drug level for long period of time lead to diminished serious GIT side effect of etoricoxib.

About the Author

Ms. Tabasubano Shekh has obtained her graduation in Pharmacy i.e. B.Pharm. Her main area of research are Novel Drug Delivery System in particular the Osmotically Controlled Drug Delivery System. She has Industrial experience in Drug Regulatory Affaires Department. She Published number of research and review papers in various journals.