The Development of the Red Pulp in the Spleen (Advances in Anatomy, Embryology and Cell Biology)

Volker Grouls Burkhard Helpap

ISBN 10: 3540114084 / ISBN 13: 9783540114086

Published by Springer Berlin Heidelberg 1982-01-01, 1982

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Seller Inventory # 6666-IUK-9783540114086

Bibliographic Details

• Title: The Development of the Red Pulp in the Spleen (Advances in Anatomy, Embryology and Cell Biology)
• Publisher: Springer Berlin Heidelberg 1982-01-01
• Publication Date: 1982
• Language: English
• ISBN 10: 3540114084
• ISBN 13: 9783540114086
• Binding: Paperback
• Condition: New

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Synopsis

In many aspects hematopoiesis in newborn rodents, especially in rats, resembles hema- topoiesis in the human fetus in the 6th-7th month of gestation. In man the transition from the stage of liver to bone marrow erythropoiesis takes place at this time (Bessis, 1973). In rodents, however, the liver is almost the only place where hematopoiesis occurs until birth. Thereafter it is replaced to a growing extent by the bone marrow, which so far consists mainly of immature mesenchymal cells (Maximow, 1910; Cuda, 1970). Thus hematopoietic precursor cells appear in the sternum only around 30 h after birth. Just as in premature human infants, a macrocytic anemia can be demonstrat- ed in normal neonatal rats (Lucarelli et aI., 1964, 1968). Beside liver (fetal) and bone marrow, the spleen is involved in hematopoiesis. In rodents like rats and mice, splenic hematopoiesis persists more or less markedly until adulthood; in man, however, it ceases after birth and reappears only under certain pathological conditions (Fischer et aI., 1970; Hennekeuser et aI., 1967; Fresen, 1960).