Development of Sustained Release Tablets of Eplerenone: Effect of Cellulose and Natural Polymers

Reddy, Sunil; Katakam, Vinay Kumar; Yamsani, Madhusudan Rao

ISBN 10: 3659222887 / ISBN 13: 9783659222887

Published by LAP LAMBERT Academic Publishing, 2012

About this Item

Seller Inventory # I-9783659222887

Bibliographic Details

• Title: Development of Sustained Release Tablets of Eplerenone: Effect of Cellulose and Natural Polymers
• Publisher: LAP LAMBERT Academic Publishing
• Publication Date: 2012
• Language: English
• ISBN 10: 3659222887
• ISBN 13: 9783659222887
• Binding: Soft cover
• Condition: New

About this title

Synopsis

The objective of this work was to develop of a suitable SR tablet formulation of Eplerenone and to study the effect of polymers such as HPMC K4M, HPMC K15M, NaCMC, Guar gum, Xanthan gum and Karaya gum on drug release. Profile and to get an optimized formulation. Eplerenone binds to the mineralo corticoid receptor and blocks the binding of aldosterone, a component of the renin-angiotensin-aldosterone system (RAAS). It has a half life of 4 hrs. When dose is missing it may cause nocturnal attack, so attention was made to develop the Sustained release tablets of Eplerenone. The purpose of controlled release systems is to maintain drug concentration in the blood or in target tissues at a desired value as long as possible. In other words, they are able to exert a control on the drug release rate and duration. In the market only IR tablets of Eplerenone were available which are costly. So there is a need to formulate SRMT of Eplerenone to reduce the cost and increase the patient compliance.

About the Author

Dr. Sunil Reddy is working as Associate Prof. at St.Peter's College of Pharmacy, Warangal, Andhrapradesh, India. He has completed B.Pharm, M.Pharm and Ph.D.from Kakatiya University, Warangal, Andhrapradesh, India. He has 10 International and 08 National Journals and contributed several book chapters. He has 20 research presentations.