Development of In Vitro Maturation for Human Oocytes: Natural and Mild Approaches to Clinical Infertility Treatment

An ideal reference for infertility specialists and reproductive endocrinologists alike, this comprehensive text discusses current natural and mild approaches to in vitro fertilization (IVF) and the development of in vitro maturation (IVM) as a clinical treatment. It is divided thematically into four sections. Part I presents the basic science of ovarian endocrinology and the mechanism of oocyte maturation, including follicular development and the importance of mitochondrial changes. The differences between natural cycle IVF and stimulated IVF are presented in part II, including the standard ovarian stimulation protocols and their outcomes and the etiology, prevention and management of ovarian hyperstimulation syndrome (OHSS). Minimal and mild stimulation for IVF is discussed in part III, including mild stimulation protocols for oncofertility patients and the new minimally invasive INVO procedure. In vitro maturation as a clinical treatment is the subject of part IV, discussing the methodology of immature oocyte retrieval as well as other laboratory aspects and congenital and obstetrical outcomes of babies born from IVM.

Combining expertise from thought leaders around the world, Development of In Vitro Maturation for Human Oocytes will be a go-to resource for infertility researchers and practitioners and reproductive endocrinologists working with infertile couples looking for safer and more cost-effective options for treatment.

Ri-Cheng Chian, MSc, PhD, Associate Professor, Department of Obstetrics and Gynecology, McGill University, Montreal, Quebec, Canada

Geeta Nargund FRCOG, Medical Director, Create Fertility, Lead consultant in Reproductive Medicine, St George's Hospital NHS Trust, President, International Society for Mild Approaches in Assisted Reproduction (ISMAAR), London, UK

Jack Y. J. Huang, MD, PhD, Assistant Professor, Stanford University School of Medicine, Director, International Patients Program and Stanford Fertility and Reproductive Medicine In Vitro Fertilization Program, Stanford University Medical Center, Stanford, CA, USA