Diclofenac Potassium Tablet for Colon Targeting: Formulation

Language: English

Published by LAP LAMBERT Academic Publishing Jul 2023, 2023

6206181219 / 9786206181217

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Neuware -The present study was to formulate tablet of Diclofenac potassium using the hydrophilic polymer hydroxy propyl methyl cellulose (HPMC), Hydroxypropyl Cellulose (HPC), Ethyl Cellulose(N22), Cross Povidone and Sodium Starch Glycolate as a superdisintegrants and Instacoat EN super II as a enteric coat to the colone specific tablet. A 33 randomized full factorial design, 3 level and 3 factors were used. The concentration of Hydroxy propyl cellulose (X1), concentration of HPMC K4M (X2) and concentration of Ethyl cellulose (X3) were selected as independent variables. The percentage drug release at 12 hours (Q12), percentage friability and hardness of tablet were selected as dependent variables for optimization study. The core, press coat tablets were compressed by rotatory tablet machine evaluated with different parameters like diameter, thickness, average weight, hardness, friability, kinetic release data. Hardness of tablets was found to be in the range of 7-8 kg/cm2. The enteric coated tablets containing diclofenac potassium released 38.12 % at the end of 12 hrs by in vitro release study. 52 pp. Englisch.

Seller Inventory # 9786206181217

Title
Diclofenac Potassium Tablet for Colon Targeting: Formulation
Author
Anilkumar Shinde
Publisher
LAP LAMBERT Academic Publishing Jul 2023
Publication year
2023
Condition
Neu
Binding
Taschenbuch
Language
English
ISBN 10
6206181219
ISBN 13
9786206181217
Item weight
96 grams
Dimensions
220x150x4 mm

Books-by-Floh

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