Diffusion-Reaction Modeling,Nonlinear Dynamics,Feedback,Bifurcation and Chaotic Behavior | of the Acetylcholine Neurocycle and their Relation to Alzheimer's and Parkinson's Diseases

Ibrahim Mustafa

ISBN 10: 3639864204 / ISBN 13: 9783639864205

Published by Scholars' Press, 2018

About this Item

Diffusion-Reaction Modeling,Nonlinear Dynamics,Feedback,Bifurcation and Chaotic Behavior | of the Acetylcholine Neurocycle and their Relation to Alzheimer's and Parkinson's Diseases | Ibrahim Mustafa | Taschenbuch | 236 S. | Englisch | 2018 | Scholars' Press | EAN 9783639864205 | Verantwortliche Person für die EU: BoD - Books on Demand, In de Tarpen 42, 22848 Norderstedt, info[at]bod[dot]de | Anbieter: preigu.

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Bibliographic Details

• Title: Diffusion-Reaction Modeling,Nonlinear Dynamics,Feedback,Bifurcation and Chaotic Behavior | of the Acetylcholine Neurocycle and their Relation to Alzheimer's and Parkinson's Diseases
• Publisher: Scholars' Press
• Publication Date: 2018
• Language: English
• ISBN 10: 3639864204
• ISBN 13: 9783639864205
• Binding: Taschenbuch
• Condition: Neu
• Dimensions: 220W x 150H x 15D millimeters 220 millimeters width by 150 millimeters height by 15 millimeters depth
• Weight: 369 grams
• Seller catalogs:
  • Bücher

About this title

Synopsis

The disturbances and abnormalities occurring in the components of the Acetylcholine (ACh) neurocycle are considered one of the main features of cholinergic sicknesses like Parkinson's and Alzheimer's diseases. A fundamental understanding of the ACh neurocycle is therefore very critical in order to design drugs that keep the ACh concentrations in the normal physiological range. In this dissertation, a novel two-enzyme-two-compartment model is proposed in order to explore the bifurcation, dynamics, and chaotic characteristics of the ACh neurocycle. The model takes into consideration the physiological events of the choline uptake into the presynaptic neuron and the ACh release in the postsynaptic neuron. In order to approach more realistic behavior, two complete kinetic mechanisms for enzymatic processes pH-dependent are the first mechanism is for the hydrolysis reaction catalyzed by the acetylcholinesterase (AChE) and the other is for the synthesis reaction catalyzed by the cholineacetyltransferase (ChAT).