During the years that have intervened since the third volume of the International Life Seiences Institute (ILSI) Monographs on Pathology of Laboratory Animals, Digestive System, was published, new information of interest to pathologists has developed at a rather remarkable pace. Standardized nomenclature has been proposed and gained significant acceptance during the period since the first edition and isbeing utilized on aninternational basis. Thishas resulted in improvement in communi- cationof pathologic data to reguiatory agencies and inscientific publica- tions worldwide. This monograph series and others sponsored by ILSI have had significant effects on improved communications and the inter- national acceptance of standardized nomenclature. In this second edition, new formats have been used in some instances where more appropriate for the subjects to be eovered. The format introduced in the first edition remains useful as it emphasizes the neces- sityto reeognize the morphologie features of pathologic lesions to iden- tify them precisely. This identifieation is an essential first step toward development of new insightsintopathogenetic meehanismsand their use in decisions eventually applieable to public health. Newinformation is included in thisedition on the nature and variability of preneoplastic lesions in the Iiver of laboratory rodents. Data on the aeeompanying changes in enzyme activity in affeeted Iiver cells are ex- panded, and additional information on spongiosis hepatis in the rat and its relation to spongiotic pericytoma is a further feature. In a few in- stanees, research on a pathologie entity has been Iimitedbut its recogni- tionremains important. Thisjustifiesinclusion of suchentities in the new edition.

From the Back Cover

This is the second edition of the third volume in the Monographs on Pathology of Laboratory Animals series. Since the first edition, new information has developed at a remarkable pace. Both editions propose standardized nomenclature that is being used internationally, gaining significant acceptance. The result is improved communications of pathologic data to regulatory agencies and in scientific publications worldwide. New information on the nature and variability of preneoplastic lesions in the liver of laboratory rodents is included in this edition. The book expands data on the accompanying changes in enzyme activity in affected liver cells. Spongiosis hepatis in the rat and its relation to spongiotic pericytoma are discussed thoroughly. Information on many other pathologic entities is brought up to date and new ones are added to this second edition, making it an even more useful and expanded reference text.

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