Dipeptidyl Aminopeptidases: Basic Science and Clinical Applications (Advances in Experimental Medicine and Biology)

Hardcover, xxiv + 239 pages, NOT ex-library. Fine unmarked interior. Cover shows mild shelfwear, gently bent tips of corners, a couple of scratches on the rear panel. Published without a dust jacket. --- This is the first comprehensive volume on Dipeptidyl Aminopeptidases that can be marketed to a wide variety of disciplines, as well as to a variety of clinicians. Leading experts in the field contribute to this state-of-the-art view on these enzymes. This book comes at a time when our understanding of their function is growing ever more rapidly and therapeutic options have become imminent. --- Contents: I. Structure and Function: 1. Peptide Substrates of Dipeptidyl Peptidases 2. Phosphorus-Containing Inhibitors of Proteolytic Enzymes 3. Biochemical Properties of Recombinant Prolyl Dipeptidases DPP-IV and DPP8 4. Prediction of Dipeptidyl Peptidase (DP) 8 Structure by Homology Modelling; II. DPIV-Related Enzymes: 1. Structure and Function in Dipeptidyl Peptidase IV and Related Proteins 6. Expression and Function of Dipeptidyl Peptidase IV and Related Enzymes in Cancer 7. DP8 and DP9 Have Extra-Enzymatic Roles in Cell Adhesion, Migration, and Apoptosis 8. In Vivo Effects of a Potent, Selective DPPII Inhibitor: UAMC00039 Is a Possible Tool for the Elucidation of the Physiological Function of DPPII 9. Expression of Dipeptidyl Peptidase IV-Like Enzymes in Human Peripheral Blood Mononuclear Cells 10. Dipeptidyl Peptidase 8 Has Post-Proline Dipeptidyl Aminopeptidase and Prolyl Endopeptidase Activities 11. Prolyl Endopeptidase Cleaves the Apoptosis Rescue Peptide Humanin and Exhibits and Unknown Post-Cysteine Cleavage Specificity 12. Distribution of Dipeptidyl Peptidase IV-Like Activity Enzymes in Canine and Porcine Tissue Sections by RT-PCR; III. Metabolic Disorders: 13. Relative Contribution of Incretins to the Glucose Lowering Effect of DP IV Inhibitors in Type 2 Diabetes Mellitus (T2DM) 14. Dipeptidyl Peptidase IV: A Molecular Switch of Vascular Actions of Neuropeptide Y; IV. Immune Disorders: 15. Dipeptidylpeptidase IV (DPIV) and Alanyl-Aminopeptidases (AAPs) as a New Target Complex for Treatment of Autoimmune and Inflammatory Diseases: Proof of Concept in a Mouse Model of Colitis 16. Dipeptidyl Peptidases and Inflammatory Bowel Disease 17. Possible Role of DP IV Inhibitors in Acne Therapy 18. Dipeptidyl Peptidase-IV Activity and/or Structure Homologs (DASH): Contributing Factors in the Pathogenesis of Rheumatic Diseases?; V. Neuronal Diseases: 19. Dipeptidyl Peptidase IV (DP IV, CD26) and Aminopeptidase N (APN, CD13) as Regulators of T Cell Function and Targets of Immunotherapy in CNS Inflammation 20. CD26/DP IV in T Cell Activation and Autoimmunity; VI. Cancer: 21. DPIV/CD26 and FAP in Cancer: A Tale of Contradictions 22. Type-II Transmembrane Prolyl Dipeptidases and Matrix Metalloproteinases in Membrane Vesicles of Active Endothelial Cells 23. Extra-Enzymatic Roles of DPIV and FAP in Cell Adhesion and Migration on Collagen and Fibronectin 24. Role of Neuropeptide Y and Dipeptidyl Peptidase IV in Regulation of Ewing's Sarcoma Growth 25. Role of CD26/DPP IV in Preservation of Early Pulmonary Graft Function.…