Dipeptidyl Aminopeptidases: Basic Science and Clinical Applications (Advances in Experimental Medicine and Biology)

Uwe Lendeckel; Dirk Reinhold; Ute Bank

ISBN 10: 0387290583 / ISBN 13: 9780387290584

Published by Springer, 2006

About this Item

Hardcover, xxiv + 239 pages, NOT ex-library. Fine unmarked interior. Cover shows mild shelfwear, gently bent tips of corners, a couple of scratches on the rear panel. Published without a dust jacket. --- This is the first comprehensive volume on Dipeptidyl Aminopeptidases that can be marketed to a wide variety of disciplines, as well as to a variety of clinicians. Leading experts in the field contribute to this state-of-the-art view on these enzymes. This book comes at a time when our understanding of their function is growing ever more rapidly and therapeutic options have become imminent. --- Contents: I. Structure and Function: 1. Peptide Substrates of Dipeptidyl Peptidases 2. Phosphorus-Containing Inhibitors of Proteolytic Enzymes 3. Biochemical Properties of Recombinant Prolyl Dipeptidases DPP-IV and DPP8 4. Prediction of Dipeptidyl Peptidase (DP) 8 Structure by Homology Modelling; II. DPIV-Related Enzymes: 1. Structure and Function in Dipeptidyl Peptidase IV and Related Proteins 6. Expression and Function of Dipeptidyl Peptidase IV and Related Enzymes in Cancer 7. DP8 and DP9 Have Extra-Enzymatic Roles in Cell Adhesion, Migration, and Apoptosis 8. In Vivo Effects of a Potent, Selective DPPII Inhibitor: UAMC00039 Is a Possible Tool for the Elucidation of the Physiological Function of DPPII 9. Expression of Dipeptidyl Peptidase IV-Like Enzymes in Human Peripheral Blood Mononuclear Cells 10. Dipeptidyl Peptidase 8 Has Post-Proline Dipeptidyl Aminopeptidase and Prolyl Endopeptidase Activities 11. Prolyl Endopeptidase Cleaves the Apoptosis Rescue Peptide Humanin and Exhibits and Unknown Post-Cysteine Cleavage Specificity 12. Distribution of Dipeptidyl Peptidase IV-Like Activity Enzymes in Canine and Porcine Tissue Sections by RT-PCR; III. Metabolic Disorders: 13. Relative Contribution of Incretins to the Glucose Lowering Effect of DP IV Inhibitors in Type 2 Diabetes Mellitus (T2DM) 14. Dipeptidyl Peptidase IV: A Molecular Switch of Vascular Actions of Neuropeptide Y; IV. Immune Disorders: 15. Dipeptidylpeptidase IV (DPIV) and Alanyl-Aminopeptidases (AAPs) as a New Target Complex for Treatment of Autoimmune and Inflammatory Diseases: Proof of Concept in a Mouse Model of Colitis 16. Dipeptidyl Peptidases and Inflammatory Bowel Disease 17. Possible Role of DP IV Inhibitors in Acne Therapy 18. Dipeptidyl Peptidase-IV Activity and/or Structure Homologs (DASH): Contributing Factors in the Pathogenesis of Rheumatic Diseases?; V. Neuronal Diseases: 19. Dipeptidyl Peptidase IV (DP IV, CD26) and Aminopeptidase N (APN, CD13) as Regulators of T Cell Function and Targets of Immunotherapy in CNS Inflammation 20. CD26/DP IV in T Cell Activation and Autoimmunity; VI. Cancer: 21. DPIV/CD26 and FAP in Cancer: A Tale of Contradictions 22. Type-II Transmembrane Prolyl Dipeptidases and Matrix Metalloproteinases in Membrane Vesicles of Active Endothelial Cells 23. Extra-Enzymatic Roles of DPIV and FAP in Cell Adhesion and Migration on Collagen and Fibronectin 24. Role of Neuropeptide Y and Dipeptidyl Peptidase IV in Regulation of Ewing's Sarcoma Growth 25. Role of CD26/DPP IV in Preservation of Early Pulmonary Graft Function.

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Bibliographic Details

• Title: Dipeptidyl Aminopeptidases: Basic Science and Clinical Applications (Advances in Experimental Medicine and Biology)
• Publisher: Springer
• Publication Date: 2006
• Language: English
• ISBN 10: 0387290583
• ISBN 13: 9780387290584
• Binding: Hardcover
• Condition: Very Good

About this title

Synopsis

Dipeptidyl Aminopeptidases exert a potent modulatory role at an interface between immune mechanisms, metabolic responses, and neuroendocrine pathways. Experimental models and clinical studies addressing the role of these enzymes and the effect of specific inhibitors pave the way to novel therapeutic concepts in immunology, rheumatology, oncology, reproductive medicine and diabetes. Leading experts in the field will contribute to this book, which will present a state-of-the-art view on these enzymes at a time when our understanding of their function is growing ever more rapidly and therapeutic options have become imminent. The sections of the book will focus on various topics including DP IV and related enzymes in: expression and function, metabolic disorders, immune mechanisms and immune disorders, neuronal diseases and cancer, and related drug development.