Disorders of Hemoglobin: Genetics, Pathophysiology, and Clinical Management (Cambridge Medicine (Hardcover))

Forget, Bernard G.

ISBN 10: 0521875196 / ISBN 13: 9780521875196

Published by Cambridge University Press, 2009

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Bibliographic Details

• Title: Disorders of Hemoglobin: Genetics, Pathophysiology, and Clinical Management (Cambridge Medicine (Hardcover))
• Publisher: Cambridge University Press
• Publication Date: 2009
• Language: English
• ISBN 10: 0521875196
• ISBN 13: 9780521875196
• Binding: Hardcover
• Edition: 2nd Edition
• Condition: new

About this title

Synopsis

This book is a completely revised new edition of the definitive reference on disorders of hemoglobin. Authored by world-renowned experts, the book focuses on basic science aspects and clinical features of hemoglobinopathies, covering diagnosis, treatment, and future applications of current research. While the second edition continues to address the important molecular, cellular, and genetic components, coverage of clinical issues has been significantly expanded, and there is more practical emphasis on diagnosis and management throughout. The book opens with a review of the scientific underpinnings. Pathophysiology of common hemoglobin disorders is discussed next in an entirely new section devoted to vascular biology, the erythrocyte membrane, nitric oxide biology, and hemolysis. Four sections deal with α and β thalassemia, sickle cell disease, and related conditions, followed by special topics. The second edition concludes with current and developing approaches to treatment, incorporating new agents for iron chelation, methods to induce fetal hemoglobin production, novel treatment approaches, stem cell transplantation, and progress in gene therapy.

About the Authors

Martin H. Steinberg is Professor of Medicine, Pediatrics, Pathology and Laboratory Medicine at Boston University School of Medicine. He is also Director at the Center of Excellence in Sickle Cell Disease, Boston Medical Center.

Bernard G. Forget is Professor of Internal Medicine and Genetics at Yale University School of Medicine.

Douglas R. Higgs is Professor of Molecular Haematology at the University of Oxford.

David J. Weatherall is Regius Professor of Medicine Emeritus at the University of Oxford and Chancellor at Keele University.