This major new edition fulfils the need for a single-volume, up-to-date information resource on the etiology, pathogenesis, diagnosis and treatment of diseases of skeletal muscles, including the muscular dystrophies, mitochondrial myopathies, metabolic myopathies, ion channel disorders, and dysimmune myopathies. As background to the clinical coverage, relevant information on advances in molecular and developmental biology, immunopathology, mitochondrial biology, ion-channel dynamics, cell membrane and signal transduction science, and imaging technology is summarized. Combining essential new knowledge with the fundamentals of history-taking and clinical examination, this extensively illustrated book will continue to be the mainstay for practising physicians and biomedical scientists concerned with muscle disease. Regular updates on the clinical and basic science aspects of muscle disease - written mainly by rising stars of myology - will be published on an accompanying website.

About the Authors

George Karpati is Isaac Walton Killam Chair and Professor at the Department of Neurology and Neurosurgery, McGill University, and the Montreal Neurological Institute, Montreal, Quebec, Canada.

David Hilton-Jones is Clinical Director of the Muscular Dystrophy Campaign Muscle and Nerve Centre, John Radcliffe Hospital, Oxford, UK.

Kate Bushby is Professor of Neuromuscular Genetics at the Institute of Human Genetics, International Centre for Life, Newcastle upon Tyne, UK.

Robert C. Griggs is Professor of Neurology, Medicine, Pediatrics, Pathology and Laboratory Medicine at the Department of Neurology, University of Rochester School of Medicine and Dentistry and Strong Memorial Hospital, Rochester, New York, USA. He is also Chair of the Muscle Study Group Executive Committee.

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