A Dissertation Report on Tuberculosis Immunology: Analysis of differentially expressed proteins and sero-reactivity of Mycobacterium tuberculosis clinical isolates in comparison to lab strain H37Rv

GAURAV SHARMA, Dr. Beenu Joshi

ISBN 10: 3639343859 / ISBN 13: 9783639343854

Published by VDM Verlag Dr. M�ller 2011-03-28, 2011

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Seller Inventory # 6666-IUK-9783639343854

Bibliographic Details

• Title: A Dissertation Report on Tuberculosis Immunology: Analysis of differentially expressed proteins and sero-reactivity of Mycobacterium tuberculosis clinical isolates in comparison to lab strain H37Rv
• Publisher: VDM Verlag Dr. M�ller 2011-03-28
• Publication Date: 2011
• Language: English
• ISBN 10: 3639343859
• ISBN 13: 9783639343854
• Binding: Paperback
• Condition: New

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Synopsis

Tuberculosis (TB) is the major cause of death worldwide. The enormity of the problem has been further worsened by the emergence of multi-drug resistant (MDR) strains and the dual infection with HIV. A newly identified TB threat which leaves patients virtually untreatable using currently available anti-TB drugs is XDR-TB. Protein extracted from whole cell lysate (WCL) during late log growth phase often considered candidate components for diagnosis of Tuberculosis and vaccine.In any cell proteins are ultimately working moiety, therefore proteomic analysis and seroreactivity in relation to identify a molecule could be much informative. This study includes the analysis and comparison of whole cell lysate proteins of two clinical isolates with M. tuberculosis H37Rv strain and their reactivity for searching a immunodominant antigen. Present study suggest that current clinical isolate of M. tuberculosis might be valuable to characteristics some unique dominant targets for tuberculosis diagnosis and for vaccine candidate.

About the Author

Gaurav Sharma is a biotechnologist with research interest in interdisciplinary field of Science. Currently, he is a Indian Counsil of Medical Research Fellow and pursuing PhD at All India Institute of Medical Sciences, New Delhi, India.