Divalproex sodium floating microspheres - Design and Quantification

Language: English

Published by LAP LAMBERT Academic Publishing Jul 2018, 2018

6139893119 / 9786139893119

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Seller: BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, GermanyBuchWeltWeit Ludwig Meier e.K.

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Softcover

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This item is printed on demand - it takes 3-4 days longer - Neuware -Any drug delivery system that enhances the therapeutic effectiveness of incorporated drugs by providing sustained, controlled delivery and or targeting the drug to desired site is always invitable. Among various route of administration oral route is the most compact, painless, safest and least expensive, it is the most often used. The present study aimed to develop a floating microsphere of Divalproex sodium for Epilepsy. The microspheres were prepared by emulsification crosslinking method using gluteraldehyde as crosslinking agent and chitosan as polymer. The microspheres were characterized for pre and post compression evaluations. In- vitro percentage drug release results shown that there was markedly extended release when chitosan concentration and molecular weight was increased. This may due to crosslinking of aldehyde groups of the glutaraldehyde form covalent amine bonds with the amino groups of chitosan and also due to the resonance established with adjacent double ethylenic bonds via Schiff reaction.Thus, this approach could be beneficial for the treatment of epilepsy with improved dissolution and absorption. 124 pp. Englisch.…

Seller Inventory # 9786139893119

Title
Divalproex sodium floating microspheres - Design and Quantification
Author
Subashini Rajaram
Publisher
LAP LAMBERT Academic Publishing Jul 2018
Publication year
2018
Condition
Neu
Binding
Taschenbuch
Language
English
ISBN 10
6139893119
ISBN 13
9786139893119
Item weight
203 grams
Dimensions
220x150x8 mm

BuchWeltWeit Ludwig Meier e.K.

Bergisch Gladbach, Germany

5-star seller

AbeBooks seller since January 11, 2012

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BuchWeltWeit Ludwig Meier e.K.

Germany