Drug-DNA Interaction Protocols

Language: English

Published by Humana Dez 2009, 2009

1603274170 / 9781603274173

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This item is printed on demand - Print on Demand Titel. Neuware -DNA has been known to be the cellular target for many cytotoxic anticancer agents for several decades. The knowledge of its structure in atomic detail and the ease with which DNA fragments (both synthetic oligonucleotides and natural sequences) can be prepared and manipulated has aided the design of compounds that bind to it with improved sel- tivity. On the basis of this information, new generations of sequence reading compounds (including triplex forming oligonucleotides and minor groove binding ligands) have been prepared, which have the potential for targeting specifc DNA sequences as anti-gene agents. Within the last 10 years, it has also become apparent that the familiar DNA duplex is not the only structure that can be targeted by DNA-binding ligands and there has been increased interest in triplex and quadruplex structures as drug targets, as well as protein- DNA complexes, such as those with nucleosomes or topoisomerases. Each of these advances has required the availability and development of an arsenal of techniques for probing the interactions in both qualitative and quantitative terms. This v- ume of Methods in Molecular Biology brings together several techniques that are currently useful for examining these interactions. Some of these are updates on ones that were included in the earlier volume (Methods in Molecular Biology 90), published 12 years ago, while others are new.Springer-Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 332 pp. Englisch.…

Seller Inventory # 9781603274173

Title
Drug-DNA Interaction Protocols
Author
Keith R. Fox
Publisher
Humana Dez 2009
Publication year
2009
Condition
Neu
Binding
Buch
Language
English
ISBN 10
1603274170
ISBN 13
9781603274173
Edition
2nd Edition
Item weight
899 grams
Dimensions
260x183x25 mm

buchversandmimpf2000

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