Drug Delivery Applications of Noninvasive Imaging: Validation from Biodistribution to Sites of Action

Cost-effective strategies for designing novel drug delivery systems that target a broad range of disease conditions

In vivo imaging has become an important tool for the development of new drug delivery systems, shedding new light on the pharmacokinetics, biodistribution, bioavailability, local concentration, and clearance of drug substances for the treatment of human disease, most notably cancer. Written by a team of international experts, this book examines the use of quantitative imaging techniques in designing and evaluating novel drug delivery systems and applications.

Drug Delivery Applications of Noninvasive Imaging offers a full arsenal of tested and proven methods, practices and guidance, enabling readers to overcome the many challenges in creating successful new drug delivery systems. The book begins with an introduction to molecular imaging. Next, it covers:

• In vivo imaging techniques and quantitative analysis
• Imaging drugs and drug carriers at the site of action, including low-molecular weight radiopharmaceuticals, peptides and proteins, siRNA, cells, and nanoparticles
• Applications of imaging techniques in administration routes other than intravenous injection, such as pulmonary and oral delivery
• Translational research leading to clinical applications
• Imaging drug delivery in large animal models
• Clinical applications of imaging techniques to guide drug development and drug delivery

Chapters are based on a thorough review of the current literature as well as the authors' firsthand experience working with imaging techniques for the development of novel drug delivery systems.

Presenting state-of-the-technology applications of imaging in preclinical and clinical evaluation of drug delivery systems, Drug Delivery Applications of Noninvasive Imaging offers cost-effective strategies to pharmaceutical researchers and students for developing drug delivery systems that accurately target a broad range of disease conditions.

CHUN LI, PhD, is Professor and Ad Interim Chief, Chemistry Section, in the Department of Cancer Systems Imaging at the University of Texas MD Anderson Cancer Center. He is Associate Editor of Cancer Nanotechnology and a member of the editorial boards of American Journal of Nuclear Medicine and Molecular Imaging and Quantitative Imaging in Medicine and Surgery. Dr. Li has more than 120 peer-reviewed publications and holds twenty-eight patents.

MEI TIAN, MD, is Vice President of Hangzhou Binjiang Hospital and Professor of Diagnostic Imaging and Nuclear Medicine at The Second Hospital, Zhejiang University School of Medicine. Dr. Tian is also an editorial consultant for The Lancet. She is a member of the editorial boards of Journal of Nuclear Medicine, European Journal of Nuclear Medicine and Molecular Imaging, Nuclear Medicine Communications, and Oncology.