Drug-Drug Interactions

Authored by renowned leaders in the field, this comprehensive volume covers all aspects of drug-drug interactions, including preclinical, clinical, toxicological, and regulatory perspectives.

Thoroughly updated, this second edition reflects the significant advances and includes extensive new material on:

• key interplay between transporters and enzymes in drug metabolism and drug interactions
• the integral role of pharmacogenetics in metabolism-based drug-drug interactions
• in vivo – in vitro correlations (reversible, mechanism-based inhibition, induction)
• in silico approaches enabling structure-activity and structure-function studies
• high-throughput screening and GLP methods for evaluating drug interactions in vitro
• the use of transgenic animal models to evaluate drug interactions

Providing helpful case examples and computer-aided modeling, Drug-Drug Interactions is filled with over 200 invaluable tables, equations, and figures to clarify key concepts, and incorporates critical new updated information.

A. DAVID RODRIGUES is Executive Director, Metabolism and Pharmacokinetics, Bristol-Myers Squibb, Pharmaceutical Research Institute, Princeton, NJ, and received his Ph.D. in Biochemistry from the University of Surrey, Guildford, UK. Dr. Rodrigues is a member of the American Association of Pharmaceutical Scientists and is presently serving on the Scientific Affairs Committee of the International Society for the Study of Xenobiotics. He has authored more than 75 peer-reviewed articles and over one dozen book chapters, and sits on the Editorial Board of three journals (Drug Metabolism and Disposition, Drug Metabolism Letters, and Current Drug Metabolism).