Drug-Like Properties : Concepts, Structure Design and Methods from Adme to Toxicity Optimization

Language: English

Published by Elsevier Inc Mär 2016, 2016

0128010762 / 9780128010761

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Neuware - Of the thousands of novel compounds that a drug discovery project team invents and that bind to the therapeutic target, only a fraction have sufficient ADME (absorption, distribution, metabolism, elimination) properties, and acceptable toxicology properties, to become a drug product that will successfully complete human Phase I clinical trials. Drug-Like Properties: Concepts, Structure Design and Methods from ADME to Toxicity Optimization, Second Edition, provides scientists and students the background and tools to understand, discover, and develop optimal clinical candidates. This valuable resource explores physiochemical properties, including solubility and permeability, before exploring how compounds are absorbed, distributed, and metabolized safely and stably. Review chapters provide context and underscore the importance of key concepts such as pharmacokinetics, toxicity, the blood-brain barrier, diagnosing drug limitations, prodrugs, and formulation. Building on those foundations, this thoroughly updated revision covers a wide variety of current methods for the screening (high throughput), diagnosis (medium throughput) and in-depth (low throughput) analysis of drug properties for process and product improvement. From conducting key assays for interpretation and structural analysis, the reader learns to implement modification methods and improve each ADME property. Through valuable case studies, structure-property relationship descriptions, and structure modification strategies, Drug-Like Properties, Second Edition, offers tools and methods for ADME/Tox scientists through all aspects of drug research, discovery, design, development, and optimization.…

Seller Inventory # 9780128010761

Title
Drug-Like Properties : Concepts, Structure Design and Methods from Adme to Toxicity Optimization
Author
Edward H. Kerns
Publisher
Elsevier Inc Mär 2016
Publication year
2016
Condition
Neu
Binding
Buch
Language
English
ISBN 10
0128010762
ISBN 13
9780128010761
Edition
2nd Edition
Item weight
1,777 grams
Dimensions
283x225x35 mm

AHA-BUCH GmbH

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