Drugs and a Methodological Compendium: From Bench to Bedside

This book provides a meticulous view on methodological drug discovery and development insights from bench to bedside. The current book threads almost each step encompassing drug the discovery and development of a molecule. The chapters focus on computational modus operandi, pharmacological optimization approaches, modern high-throughput screening methods and in-vitro procedures, role of structural biologists in drug discovery and development,  medicinal chemistry approaches for drug design, formulation and drug delivery, in-vivo evaluations of candidate molecules, clinical trial procedures and others. The book also covers specific case studies, regulatory approval proceedings, and industrial view point alongside the aforementioned conceptual layout. And at the same time, the volume integrates medical, biological, medicinal, pharmacological and computational streams, and it is suggested as an ideal guideline to a wide audience including molecular biologists, biochemist, pharmacologists, medicinal chemist, toxicologists, drug discovery and development researchers, and all other students interested in these disciplines.

Vikrant Singh Rajput graduated with B. Tech in Biotechnology (2010) from Amity University, Noida, UP, India, a Ph.D in Biological Science from CSIR-Indian Institute of Integrative Medicine, Jammu, J&K, India (2017). He was awarded postdoctoral fellowship from Indian Institute of Technology (IIT) Roorkee and Young Scientist Award/Research grant from Department of Health Research (Govt. of India). He has also held different positions like Adhoc Faculty at National Institute of Technology (NIT) Raipur, Project scientist at Biosafety Support Unit, Regional Centre for Biotechnology, Faridabad and Scientist at Foundation for Neglected Diseases Research, Bengaluru. He currently works as Assistant Professor at Dept. of Biomedical Engineering, Central University of Rajasthan Ajmer.

Areas of interest: TB biology; TB and anti-bacterial drug discovery; Technologies evaluating PK/PD of TB drugs, Combatting drug resistance; Novel drug targets; Computational drug discovery and immunoinformatics.

Ashish Runthala graduated with M.Sc. in Biological Science (2005) from BITS Pilani, Rajasthan, India. Meanwhile qualifying the National Eligibility test (NET), he pursued the M.E. in Biotechnology (2008) here and completed Ph.D in Computational Biology in 2016. He was awarded the Ucchayatar Avishkar Yojana (UAY) in 2017 from Indian Institute of Science. Starting his academic responsibilities at BITS Pilani from 2005, he has held several positions viz. Teaching Assistant, Assistant Lecturer, Lecturer and Visiting Faculty. He has also worked at Presidency University Bangalore as an Assistant Professor. He is currently working as an Associate Professor at KL University, Vijayawada, and is doing research on developing the functionally improved enzymes of the DXP pathway for enhancing the overall yield of the pathway.

Areas of interest: Computational algorithms; Bioinformatics; Protein structure prediction; Enzyme design; Decoding active site; Designing thermostable enzyme.