Dual Drug Action of Drug Delivery System

Pramod Kumar Biswal

ISBN 10: 3659787450 / ISBN 13: 9783659787454

Published by LAP LAMBERT Academic Publishing, 2015

About this Item

nach der Bestellung gedruckt Neuware - Printed after ordering - The purpose of the present research was to produce a quick/slow biphasic delivery system for Diclofenac Sodium. A dual component tablet made of a sustained release tableted core and an immediate release tableted coat was prepared by direct compression. Both the core and the coat contained a model drug (Diclofenac Sodium). The sustained release effect was achieved with a polymer (Microcrystalline cellulose) to modulate the release of the drug. The in vitro drug release profile from these tablets showed the desired biphasic release behavior: the Diclofenac Sodium contained in the fast releasing component was dissolved within 2 minutes, whereas the drug in the core tablet was released at different times (=16 or 924 hours), depending on the composition of the matrix tablet. Based on the release kinetic parameters calculated, it can be concluded that the Micro Crystalline core was suitable for providing a constant and controlled release (zero order) for a long period of time.

Seller Inventory # 9783659787454

Bibliographic Details

• Title: Dual Drug Action of Drug Delivery System
• Publisher: LAP LAMBERT Academic Publishing
• Publication Date: 2015
• Language: English
• ISBN 10: 3659787450
• ISBN 13: 9783659787454
• Binding: Taschenbuch
• Condition: Neu
• Dimensions: 220W x 150H x 6D millimeters 220 millimeters width by 150 millimeters height by 6 millimeters depth
• Weight: 137 grams

About this title

Synopsis

The purpose of the present research was to produce a quick/slow biphasic delivery system for Diclofenac Sodium. A dual component tablet made of a sustained release tableted core and an immediate release tableted coat was prepared by direct compression. Both the core and the coat contained a model drug (Diclofenac Sodium). The sustained release effect was achieved with a polymer (Microcrystalline cellulose) to modulate the release of the drug. The in vitro drug release profile from these tablets showed the desired biphasic release behavior: the Diclofenac Sodium contained in the fast releasing component was dissolved within 2 minutes, whereas the drug in the core tablet was released at different times (≈16 or 924 hours), depending on the composition of the matrix tablet. Based on the release kinetic parameters calculated, it can be concluded that the Micro Crystalline core was suitable for providing a constant and controlled release (zero order) for a long period of time.

About the Author

I am Pramod Kumar Biswal, currently working as Assistant Professor in Kunuwar Haribansh Singh college of Pharmacy, Jaunpur, U.P., India.