EFFECT OF EXOGENOUS LEPTIN ADMINISTRATION: ON TESTICULAR FUNCTION IN ADULT MALE SPRAGUE DAWLEY RATS

Haron, Mohd Nizam, Jeet, Harbindar, Jaafar, Hasnan

ISBN 10: 3838346033 / ISBN 13: 9783838346038

Published by LAP Lambert Academic Publishing, 2010

About this Item

LIKE NEW. SHIPS FROM MULTIPLE LOCATIONS.

Seller Inventory # ERICA79638383460336

Bibliographic Details

• Title: EFFECT OF EXOGENOUS LEPTIN ADMINISTRATION: ON TESTICULAR FUNCTION IN ADULT MALE SPRAGUE DAWLEY RATS
• Publisher: LAP Lambert Academic Publishing
• Publication Date: 2010
• Language: English
• ISBN 10: 3838346033
• ISBN 13: 9783838346038
• Binding: Paperback
• Condition: Like New
• Book Type: book

About this title

Synopsis

Leptin, a 16 k-Da protein, has been shown to have roles in diverse physiological processes, such as regulation of body weight and food intake, immune function, hematopoeisis and reproduction. Hypogonadotropic hypogonadism and infertility are common features in leptin deficient ob/ob mice. Exogenous leptin administration increases testicular and seminal vesicle weight, and elevates sperm counts and restores reproductive capacity in leptin deficient mice. Although the effects of leptin deficiency on reproduction are well recognised, the effect of excess leptin on male reproductive function in non-deficient animals is not clear. Sperm quantity and quality have both been negatively correlated with BMI, and DNA fragmentation Index has been found to correlate significantly with BMI. The factor/s involved in obesity related alterations in reproductive function remains unknown. Since leptinaemia is commonly evident in obese individuals we wondered if leptin could be responsible for the reported negative correlation between BMI and sperm quantity and quality. We therefore examined the effect of exogenous leptin administration on sperm count and sperm morphology in adult normal rats.