Early Drug Development: Bringing a Preclinical Candidate to the Clinic (Methods and Principles in Medicinal Chemistry)

Giordanetto, Fabrizio, Raimund Mannhold Helmut Buschmann u. a.:

ISBN 10: 3527341498 / ISBN 13: 9783527341498

Published by Wiley-VCH, 2018

About this Item

816 Seiten; 9783527341498.3 Gewicht in Gramm: 4.

Seller Inventory # 954445

Bibliographic Details

• Title: Early Drug Development: Bringing a Preclinical Candidate to the Clinic (Methods and Principles in Medicinal Chemistry)
• Publisher: Wiley-VCH
• Publication Date: 2018
• Language: English
• ISBN 10: 3527341498
• ISBN 13: 9783527341498
• Binding: hardcover
• Condition: Gut
• Weight: 4 grams
• Seller catalogs:
  • Varia

About this title

Synopsis

This one-stop reference systematically covers key aspects in early drug development that are directly relevant to the discovery phase and are required for first-in-human studies.
Its broad scope brings together critical knowledge from many disciplines, ranging from process technology to pharmacology to intellectual property issues.
After introducing the overall early development workflow, the critical steps of early drug development are described in a sequential and enabling order: the availability of the drug substance and that of the drug product, the prediction of pharmacokinetics and -dynamics, as well as that of drug safety. The final section focuses on intellectual property aspects during early clinical development. The emphasis throughout is on recent case studies to exemplify salient points, resulting in an abundance of practice-oriented information that is usually not available from other sources.
Aimed at medicinal chemists in industry as well as academia, this invaluable reference enables readers to understand and navigate the challenges in developing clinical candidate molecules that can be successfully used in phase one clinical trials.

About the Author

Fabrizio Giordanetto graduated in Medicinal Chemistry (Genoa, Italy) followed by his Ph.D. (London, UK) while working for the chemistry unit of Pharmacia – Pfizer (Italy). After positions at AstraZeneca (Sweden) as Principal Scientist and Project Leader and at Taros (Germany) as Head of Medicinal Chemistry, he has recently joined DE Shaw Research LLC (New York, USA) where he leads medicinal chemistry activities and drug discovery projects. During his career, he worked on several drug discovery programs resulting in multiple clinical candidates spanning oncology, CNS, inflammation, metabolic and cardiovascular indications and >100 international patents, peer–reviewed publications and book chapters.