Selenium, which is an important microelement for human health, plays a critical role in a wide variety of homeostatic processes through selenoproteins. These include endoplasmic reticulum homeostasis, immune response, regulation of transcription factors and apoptosis, control of the cellular redox state, and development of the central nervous system. Unfortunately, due to the narrow safe dose range of selenium intake, selenium deficiency and selenium excess can both yield adverse effects for human health. Low selenium status has been implicated in an increased risk of mortality, poor immune function, as well as some diseases such as Keshan disease, cretinism, and cognitive decline. Selenium excess leads to some side effects, e.g., hair loss, dermatitis, an elevated risk of diseases such as type 2 diabetes, and the occurrence of some neurological signs such as amyotrophic lateral sclerosis, hyperreflexia, convulsions, and motor weakness, etc. Considering the roles of Se in human health, selenium has gradually become a focal point of scientific research. Including, but not limited to, selenium, the Special Issue highlights the effects of micronutrient intake on human health.

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We first started out as ?The Paperback Exchange,? a chain of physical bookstores where we would part exchange your beloved books for new stories to transport you to faraway places. However, as shopping started to evolve to online shops and marketplaces, we bid our stores goodbye to become ?PBShop.? This transition has only allowed us to blossom as we now ship thousands of titles to book lovers across the globe. We pride ourselves in being a community of local book lovers which allows our passion and devotion to shine in everything we do. In 2020 we not only celebrated our 20th birthday but our 1st birthday as being completely employee owned after becoming an E.O.T in September 2019. We are proud to be different and embrace standing apart on a book mountain by working from a virtual inventory which allows us to provide thousands of books that may be difficult to get for your bookshelf or your studies. Working with a number of different suppliers allows us to explore other avenues such as puzzles, sheet music and even stationery so we really do have something for everyone. Life is about being versatile in all realms of existence. If this is your first visit or you are a returning customer, we would like to welcome you to the PBShop family, for there is no friend as loyal as a book. We are a company who put our customers at the centre of everything we do as we understand the importance of reading because once you learn to read, you will forever be free. There are a whole lot of things in this world of ours that we are yet to explore, which is why we will forever inspire curious minds.

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