Nuclear analytical techniques have many advantages over other techniques, such as high sensitivity and precision. They couple powerful selective separation with sensitive element-specific detection. The uses of metalloproteomics studies are restricted to the fields of analytical and nuclear chemistry. They also have great potential to elucidate the origins of certain diseases and assist in their diagnosis and treatment via the development of new drugs. Nuclear Analytical Techniques for Metallomics and Metalloproteomics provides readers with a comprehensive view of this relatively new and exciting area of bioanalytical and inorganic chemistry. It contains contributions from experts in disciplines as diverse as analytical chemistry, nuclear chemistry, environmental science, molecular biology and medicinal chemistry. Various nuclear analytical techniques are covered including neutron activation analysis, X-ray fluorescence, isotope tracer, M÷ssbauer spectrometry, X-ray absorption spectrometry, and neutron scattering and diffraction. They provide useful information both for chemical speciation analysis and structural characterization of metalloproteins and metals in biological systems. Consequently, the book is not only relevant for chemists involved in nuclear techniques and speciation, but also environmental, nutritional and clinical researchers and drug developers.
Professor Chunying Chen received her Bachelor's degree in chemistry (1991) and obtained her PhD degree (1996) in Biomedical engineering from Huazhong University of Science and Technology of China. She held postdoctoral positions at the Key Laboratory of Nuclear Analytical Techniques, Institute of High Energy Physics of Chinese Academy of Sciences (1996-1998) and at the Medical Nobel Institute for Biochemistry of Karolinska Institute, Sweden (2001-2002). Dr. Chen currently is a principal investigator at CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety in National Center for Nanoscience and Technology of China. She has authored or co-authored over 70 peer-reviewed papers or book chapters and three patents. She is a member of the International Union of Pure and Applied Chemistry (IUPAC), and Chinese Society of Toxicology. Her current research interests include the development of analytical approaches for metallomics and metalloproteomics such as isotopic labeling and synchrotron radiation based techniques that allow the detection of interaction of metal and molecular species; the potential toxicity of nanoparticles used for nanotechnology applications; the therapy for malignant tumor using nanoparticles for their immunomodulatory effects, drug delivery and tumor targeting; extensive in vitro and in vivo studies in cellular uptake and intracellular trafficking of nanoparticles and tissue and cellular targeting for cancer treatment; the improvement of HIV vaccine treatment by novel nanotechnology using nanomaterials as potential non-viral vectors; public health impact of long-term exposure of metals in susceptible population strata.
Professor Zhifang Chai is a radiochemist working at the Multidisciplinary Initiative Centre, Institute of High Energy Physics, the Chinese Academy of Sciences. He graduated from Fudan University, China, in 1964. As a fellow of the Alexander von Humboldt Foundation, Germany, he worked at Cologne University from 1980 to 1982 in the field of nuclear technology and its applications. Later, he worked in France, the USA, the Netherlands and Japan. He has long been involved in the methodology of nuclear analytical techniques and their multidisciplinary applications, especially in the study of the chemical speciation of trace elements in environmental and biological systems. He has authored or co-authored over 332 papers in peer-reviewed journals, 6 Chinese books and 3 English books. He is a titular member of Analytical Chemistry Division, International Union for Pure and Applied Chemsitry, Fellow of Royal Society of Chemistry, UK, and many domestic and international scientific societies. He is a member of editorial board or advisory committee of 10 international and national journals. In 2005 he was awarded the George von Hevesy Award - the premier international award of excellence to honour outstanding achievements in radioanalytical and nuclear chemistry. In 2007 he was elected as a member (Academician) of the Chinese Academy of Sciences. His present interest is to develop novel nuclear analytical methods for the study of metallomics.
Yuxi Gao is an associate professor at Institute of High Energy Physics, Chinese Academy of Sciences. He obtained his PhD degree in environmental sciences in 2000 from Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences. His current research focuses on the methodology of metallomics and metalloproteomics based on the nuclear analytical techniques; the applications of metallomics and metalloproteomics tourniquets on the environmental and biomedical research; the homeostasis of trace elements and their regulatory mechanism; the structure, function and structure-function relationship of important metalloproteins.
