Self Emulsifying Drug Delivery System | Dissolution enhancement of Ibuprofen using Response surface methodology

Md. Ismail Hossain (u. a.)

ISBN 10: 3659174386 / ISBN 13: 9783659174384

Published by LAP Lambert Academic Publishing, 2012

About this Item

Self Emulsifying Drug Delivery System | Dissolution enhancement of Ibuprofen using Response surface methodology | Md. Ismail Hossain (u. a.) | Taschenbuch | Englisch | LAP Lambert Academic Publishing | EAN 9783659174384 | Verantwortliche Person für die EU: preigu GmbH & Co. KG, Lengericher Landstr. 19, 49078 Osnabrück, mail[at]preigu[dot]de | Anbieter: preigu.

Seller Inventory # 106380671

Bibliographic Details

• Title: Self Emulsifying Drug Delivery System | Dissolution enhancement of Ibuprofen using Response surface methodology
• Publisher: LAP Lambert Academic Publishing
• Publication Date: 2012
• Language: English
• ISBN 10: 3659174386
• ISBN 13: 9783659174384
• Binding: Taschenbuch
• Condition: Neu
• Seller catalogs:
  • Bücher

About this title

Synopsis

Solubility is considered as a great problem for Ibuprofen hence a solubility enhancing technique, Self-emulsifying drug delivery system (SEDDS), was considered to be developed for Ibuprofen. Capmul PG 8 was used as a co-solvent. As surfactant, hydrophilic surfactant Cremophor EL was considered. A fixed amount of Ibuprofen was added with fixed amount of excipients. Capmul PG8 showed a good solubilizing capacity which dissolved 300 mg/ml of Ibuprofen. Cremophor EL also showed a good solubilizing capacity which dissolved 300 mg/ml of Ibuprofen. A 3-level factorial design was carried out to optimize the formulation. The optimized formula contains 24.10 mg Capmul PG8 and 71.02 mg Cremophor EL which releases 27.78%, 44.6% and 74.24% ibuprofen at the mentioned time interval. The present study shows that the Capmul PG8 and Cremophor EL have increased the release profile of capsule Ibuprofen. This attempt, therefore, delivers an alternative strategy in drug product formulation for poorly water soluble drugs. Pharmaceutical technologists, Pharmacists will find it a fruitful approach specially those working on drug delivery.

About the Author

I have completed Bachelor of pharmacy from Gono University and Master of Science in Pharmaceutical Technology from University of Asia Pacific. I have Long been involved in research work and six publications have been published in international journals. Currently, working in a research project on antioxidant agents from plant sources.