Engineering Genetic Logic Gates : Design and Functional Assembly of Synthetic Biological Circuits

Baojun Wang

ISBN 10: 3659274798 / ISBN 13: 9783659274794

Published by LAP LAMBERT Academic Publishing, 2012

About this Item

nach der Bestellung gedruckt Neuware - Printed after ordering - Programming living cells with synthetic gene circuits to perform desired tasks has been a major theme in the growing field of synthetic biology. However, gene circuit engineering currently lacks the same predictability and reliability as seen in other mature engineering disciplines. This book introduces the design methodology for engineering novel modular and orthogonal genetic logic devices, and the predictable functional assembly of modular biological components into customisable biological circuits. Various genetic logic devices, including AND, NOT and NAND gates, were constructed in Escherichia coli bacteria to achieve customised cellular computing and sensing. An effective parts-based engineering approach is presented for assembling individual biological parts into functional circuits using engineered in-context characterised modules aided by modelling. The book is a pioneering work in the field, and should be useful for engineers who would like to engineer synthetic biological systems for human desired purposes and for biologists who are interested in the design principles of natural biological circuits.

Seller Inventory # 9783659274794

Bibliographic Details

• Title: Engineering Genetic Logic Gates : Design and Functional Assembly of Synthetic Biological Circuits
• Publisher: LAP LAMBERT Academic Publishing
• Publication Date: 2012
• Language: English
• ISBN 10: 3659274798
• ISBN 13: 9783659274794
• Binding: Taschenbuch
• Condition: Neu
• Dimensions: 220W x 150H x 14D millimeters 220 millimeters width by 150 millimeters height by 14 millimeters depth
• Weight: 328 grams

About this title

Synopsis

Programming living cells with synthetic gene circuits to perform desired tasks has been a major theme in the growing field of synthetic biology. However, gene circuit engineering currently lacks the same predictability and reliability as seen in other mature engineering disciplines. This book introduces the design methodology for engineering novel modular and orthogonal genetic logic devices, and the predictable functional assembly of modular biological components into customisable biological circuits. Various genetic logic devices, including AND, NOT and NAND gates, were constructed in Escherichia coli bacteria to achieve customised cellular computing and sensing. An effective parts-based engineering approach is presented for assembling individual biological parts into functional circuits using engineered ‘in-context’ characterised modules aided by modelling. The book is a pioneering work in the field, and should be useful for engineers who would like to engineer synthetic biological systems for human desired purposes and for biologists who are interested in the design principles of natural biological circuits.

About the Author

Dr Baojun Wang obtained his PhD degree in Bioengineering at Imperial College London. His research centres on the design and engineering of synthetic biological devices and circuits for customised cellular computing and sensing. He is currently a Research Fellow at Imperial and works on building an interface between cellular and electronic systems.