Engineering Genetic Logic Gates: Design and Functional Assembly of Synthetic Biological Circuits

Baojun Wang

ISBN 10: 3659274798 / ISBN 13: 9783659274794

Published by LAP LAMBERT Academic Publishing, 2012

208 pages. 8.66x5.91x0.47 inches. In Stock. Seller Inventory # 3659274798

Synopsis:

Programming living cells with synthetic gene circuits to perform desired tasks has been a major theme in the growing field of synthetic biology. However, gene circuit engineering currently lacks the same predictability and reliability as seen in other mature engineering disciplines. This book introduces the design methodology for engineering novel modular and orthogonal genetic logic devices, and the predictable functional assembly of modular biological components into customisable biological circuits. Various genetic logic devices, including AND, NOT and NAND gates, were constructed in Escherichia coli bacteria to achieve customised cellular computing and sensing. An effective parts-based engineering approach is presented for assembling individual biological parts into functional circuits using engineered ‘in-context’ characterised modules aided by modelling. The book is a pioneering work in the field, and should be useful for engineers who would like to engineer synthetic biological systems for human desired purposes and for biologists who are interested in the design principles of natural biological circuits.

About the Author: Dr Baojun Wang obtained his PhD degree in Bioengineering at Imperial College London. His research centres on the design and engineering of synthetic biological devices and circuits for customised cellular computing and sensing. He is currently a Research Fellow at Imperial and works on building an interface between cellular and electronic systems.

Bibliographic Details

Title: Engineering Genetic Logic Gates: Design and ...
Publisher: LAP LAMBERT Academic Publishing
Publication Date: 2012
Binding: Paperback
Condition: Brand New