Engineering Materials for Stem Cell Regeneration

This book reviews the interface of stem cell biology and biomaterials for regenerative medicine. It presents the applications of biomaterials to support stem cell growth and regeneration. The book discusses the stem cell interactions’ with nanofiber, gradient biomaterial, polymer- and ceramic biomaterials, integrating top-down and bottom-up approaches, adhesive properties of stem cells on materials, cell-laden hydrogels, micro-and nanospheres, de-cellularization techniques, and use of porous scaffolds. Further, this book provides a basic introduction to the fabrication techniques for creating various biomaterials that can be used for stem cell differentiation. It also elucidates the properties of stem cells, their characteristic features, tissue culture technology, properties of pluripotency, osteogenesis, and biomaterial interaction with de-cellularized organs, cell lineage in vivo and in vitro, gene expression, embryonic development, and cell differentiation.

Further, the book reviews the latest applications of bio-instructive scaffold for supporting stem cell differentiation and tissue regeneration. The book also presents stem cell for dental, alveolar bone and cardiac regeneration. Lastly, it introduces engineered stem cells for delivering small molecule therapeutics and their potential biomedical applications.

Dr. Faheem A. Sheikh is an Assistant Professor at the Department of Nanotechnology, University of Kashmir, India. He served as an Assistant Professor at the Department of Biotechnology at the Central University of Kashmir, India (2015-2016); Research Professor at the Nano-Bio Regenerative Medical Institute, Myongji University, South Korea (2014-2015); Assistant Professor at Hallym University, South Korea (2002-2014); Post-Doc/Research fellow at the University of Texas Rio Grande Valley, Texas, United States of America (2010-2012) and Research Professor at Myongji University, South Korea (2010). His research mainly focuses on fabricating nanomaterials used in tissue engineering.

Currently, he is heading a lab, which works on creating different nanomaterials that can be used in various biological applications; this includes cell culturing and microbial assays. He has considerable expertise in the fabrication of polymeric, ceramic, and metal oxide nanofibersusing electrospinning, as well as the production of porous scaffolds by solvent casting, salt-leaching, 3D printing, gas forming, sol-gel synthesis, phase separation, freeze-drying, and particulate leaching and self-assembly for hard and soft tissue engineering. He believes that we will always need new and intelligent materials to address the different challenges faced in tissue engineering science. He has more than 15 years of research experience in nanotechnology, focusing on tissue engineering and drug delivery. He has published more than 100 peer-reviewed articles and book chapters.