Enhancement of Solubility and Dissolution Rate Using Modified Guar Gum

N. R. Sheth

ISBN 10: 3659337536 / ISBN 13: 9783659337536

Published by LAP LAMBERT Academic Publishing Feb 2013, 2013

About this Item

This item is printed on demand - Print on Demand Titel. Neuware -Present study examines the effect of Guar gum (GG) and Modified guar gum (MGG) on the oral bioavailability of a poorly water-soluble drug, Ibuprofen (IBU). Modified guar gum (MGG) was prepared using heat treatment (125-130oC for 2 to 3 hours) method. It was characterized for viscosity, swelling index and water retention capacity. The physical and co-grinding mixtures of IBU with GG and MGG were prepared in 1:9 drug to gum ratio. The physical and co-grinding mixtures were characterized by DSC, FT-IR. The studies confirmed that there was no interaction between drug and carrier. Prepared mixtures were evaluated for solubility study and in vitro dissolution studies. The rank order of solubility was IBUOmniScriptum SRL, Str. Armeneasca 28/1, office 1, 2012 Chisinau 92 pp. Englisch.

Seller Inventory # 9783659337536

Bibliographic Details

• Title: Enhancement of Solubility and Dissolution Rate Using Modified Guar Gum
• Publisher: LAP LAMBERT Academic Publishing Feb 2013
• Publication Date: 2013
• Language: English
• ISBN 10: 3659337536
• ISBN 13: 9783659337536
• Binding: Taschenbuch
• Condition: Neu
• Dimensions: 220W x 150H x 7D millimeters 220 millimeters width by 150 millimeters height by 7 millimeters depth
• Weight: 155 grams

About this title

Synopsis

Present study examines the effect of Guar gum (GG) and Modified guar gum (MGG) on the oral bioavailability of a poorly water-soluble drug, Ibuprofen (IBU). Modified guar gum (MGG) was prepared using heat treatment (125-130oC for 2 to 3 hours) method. It was characterized for viscosity, swelling index and water retention capacity. The physical and co-grinding mixtures of IBU with GG and MGG were prepared in 1:9 drug to gum ratio. The physical and co-grinding mixtures were characterized by DSC, FT-IR. The studies confirmed that there was no interaction between drug and carrier. Prepared mixtures were evaluated for solubility study and in vitro dissolution studies. The rank order of solubility was IBU

About the Author

Vipul V. Jambukiya currently i am working as drug inspector at junagdha, gujarat. i did my M Pharma in Department of pharmaceutics, Saurashtra University. currently i am doing Ph. D. from Saurashtra University Under the Guidance of Dr. J. K. Patel.