Title: Enhancement of solubility and dissolution rate of Griseofulvin: Enhancement of solubility and dissolution rate of Griseofulvin using particulate drug delivery systems
Publisher: LAP LAMBERT Academic Publishing
Publication Date: 2020
Language: English
ISBN 10: 6202514124
ISBN 13: 9786202514125
Binding: Soft cover
Condition: New

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Synopsis

In the recent years, the interest in micron and submicron systems in pharmacy as surged. Micron system comes in range of μm and submicron in nm. Typically colloid is an intermediates size between molecular range and coarse range. There has been a considerable research interest in the area of drug delivery using particulate systems. Particulate systems used as a physical approach to alter and improve the pharmacokinetic and pharmacodynamic properties of various types of drug molecules. Griseofulvin is an important agent in the treatment of dermatophytosis. Results of present work lead to a conclusion that reduced size of the drug particles with presence of the surfactants and polymers on the surface of griseofulvin microparticles are responsible for meteoric rise in solubility and dissolution velocity. Surfactants play an important role in the solubility of the drugs by increasing the wettability due to adsorption on the surfaces. Microparticles have been used as a physical approach to alter and improve the pharmacokinetic and pharmacodynamic properties of various types of drug molecules due to increased surface area by several times.

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