The Enzymes in Synthesis of Chiral Bioactive Compounds

Mahmoud Morsy Mohamed, Nesrin, Hamed Imam Ismael, Eman, Abda

ISBN 10: 6138912845 / ISBN 13: 9786138912842

Published by Scholars* Press, 2019

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Bibliographic Details

• Title: The Enzymes in Synthesis of Chiral Bioactive Compounds
• Publisher: Scholars* Press
• Publication Date: 2019
• Language: English
• ISBN 10: 6138912845
• ISBN 13: 9786138912842
• Binding: paperback
• Condition: New
• Book Type: book

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Synopsis

The administration of chiral compounds in an enantiomerically pure form, instead of racemic mixtures, become an important issue especially in the pharmaceutical and agrochemical industries due to the well established correlation between the biological activity and stereochemistry. Pure enantiomers could be formed by the asymmetric synthesis and /or the resolution of racemates. This could be achieved by the use of enzymes as chiral catalysts. The advantages of enzymes are their high stereo- (chiral), regio- (positional) and chemo- (functional group specific) selectivity. This selectivity offers several benefits like high catalytic efficiency, preservation of asymmetric centres, single step transformations, easier separation, mild operating conditions and fewer environmental problems. The organic reactions that are catalyzed by enzymes to give chiral bioactive organic compounds include, for example, reduction (e.g. by dehydrogenases, ketoreductases), oxidation (e.g. by monooxygenases, dioxygenases), hydrolytic (e.g. by lipases, esterases) reactions.