Epigenetic Analysis of Human Embryonic Stem Cells : Basics, Computational Methods, Applications

Language: English

Published by Südwestdeutscher Verlag Für Hochschulschriften, 2011

3838127625 / 9783838127620

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Seller: AHA-BUCH GmbH, Einbeck, GermanyAHA-BUCH GmbH

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nach der Bestellung gedruckt Neuware - Printed after ordering - Human embryonic stem cells (hESCs) hold promise for future cell replacement therapy because they can be induced to differentiate into a wide variety of cell types. DNA methylation is a crucial epigenetic mechanism involved in normal cellular differentiation. The author Lukas Chavez introduces into several experimental and computational methods commonly applied for the analysis of genetic and epigenetic characteristics. Subsequently, he develops and comprehensively describes computational methods for the analysis of novel genome-wide DNA methylation data. In a case study, the computational methods are applied to DNA methylation data derived from hESCs. The author analyzes the interplay between DNA methylation, histone modifications, and transcription factor binding, and investigates the effect of differential methylation on gene expression. The results given in this book extend our knowledge of interactions between genetic and epigenetic mechanisms during early differentiation of hESCs. The book is of most interest not only for stem cell biologists but also for researchers interested in computational methods available for high-throughput studies in health and disease.…

Seller Inventory # 9783838127620

Title
Epigenetic Analysis of Human Embryonic Stem Cells : Basics, Computational Methods, Applications
Author
Lukas Chávez
Publisher
Südwestdeutscher Verlag Für Hochschulschriften
Publication year
2011
Condition
Neu
Binding
Taschenbuch
Language
English
ISBN 10
3838127625
ISBN 13
9783838127620
Item weight
227 grams
Dimensions
220x150x9 mm

AHA-BUCH GmbH

Einbeck, Germany

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