Epigenetic Analysis of Human Embryonic Stem Cells | Basics, Computational Methods, Applications

Lukas Chávez

ISBN 10: 3838127625 / ISBN 13: 9783838127620

Published by Südwestdeutscher Verlag für Hochschulschriften, 2015

About this Item

Epigenetic Analysis of Human Embryonic Stem Cells | Basics, Computational Methods, Applications | Lukas Chávez | Taschenbuch | 140 S. | Englisch | 2015 | Südwestdeutscher Verlag für Hochschulschriften | EAN 9783838127620 | Verantwortliche Person für die EU: preigu GmbH & Co. KG, Lengericher Landstr. 19, 49078 Osnabrück, mail[at]preigu[dot]de | Anbieter: preigu.

Seller Inventory # 106744788

Bibliographic Details

• Title: Epigenetic Analysis of Human Embryonic Stem Cells | Basics, Computational Methods, Applications
• Publisher: Südwestdeutscher Verlag für Hochschulschriften
• Publication Date: 2015
• Language: English
• ISBN 10: 3838127625
• ISBN 13: 9783838127620
• Binding: Taschenbuch
• Condition: Neu
• Dimensions: 220W x 150H x 9D millimeters 220 millimeters width by 150 millimeters height by 9 millimeters depth
• Weight: 227 grams
• Seller catalogs:
  • Bücher

About this title

Synopsis

Human embryonic stem cells (hESCs) hold promise for future cell replacement therapy because they can be induced to differentiate into a wide variety of cell types. DNA methylation is a crucial epigenetic mechanism involved in normal cellular differentiation. The author Lukas Chavez introduces into several experimental and computational methods commonly applied for the analysis of genetic and epigenetic characteristics. Subsequently, he develops and comprehensively describes computational methods for the analysis of novel genome-wide DNA methylation data. In a case study, the computational methods are applied to DNA methylation data derived from hESCs. The author analyzes the interplay between DNA methylation, histone modifications, and transcription factor binding, and investigates the effect of differential methylation on gene expression. The results given in this book extend our knowledge of interactions between genetic and epigenetic mechanisms during early differentiation of hESCs. The book is of most interest not only for stem cell biologists but also for researchers interested in computational methods available for high-throughput studies in health and disease.

About the Author

Lukas Chávez obtained his PhD in Computational Biology at the Max-Planck-Institute for Molecular Genetics and Freie Universität Berlin. Currently, he works as a PostDoc at the Max-Planck-Institute for Molecular Genetics where he analyzes epigenetic modifications during cancer development.