The Evolution from Protein Chemistry to Proteomics: Basic Science to Clinical Application: Applications in Solution Protein Chemistry

Roger L. Lundblad

ISBN 10: 0849396786 / ISBN 13: 9780849396786

Published by CRC Press, USA, 2005

About this Item

0849396786. Ex library, pictorial board hardcover. Lending record shows this book has never been borrowed. 312 pages, index, illustrated. Protein modification to proteomic research, covering sample preparation, sample prefractionation, analytical technologies, and validation. Merges current proteomics concepts into established solution protein chemistry concepts. Proteomics is being applied to broader areas of experimental biology, ranging from oncology research to plant biology and environmental health. Discusses analytical proteomics, expression proteomics, and clinical proteomics. Presents specifics on the prefractionation of samples used to identify specific subproteomes such as phosphoproteomes and glycoproteomes. Reviews of the chemical modification of proteins, including its use for chemical proteomics. 2006 edition. Contents as new, clean, tight and bright.

Seller Inventory # 027009

Bibliographic Details

• Title: The Evolution from Protein Chemistry to Proteomics: Basic Science to Clinical Application: Applications in Solution Protein Chemistry
• Publisher: CRC Press, USA
• Publication Date: 2005
• Language: English
• ISBN 10: 0849396786
• ISBN 13: 9780849396786
• Binding: Hardcover
• Edition: 2006.
• Condition: Near Fine
• Book Type: Book
• Seller catalogs:
  • Biotechnology

About this title

Synopsis

Largely driven by major improvements in the analytical capability of mass spectrometry, proteomics is being applied to broader areas of experimental biology, ranging from oncology research to plant biology to environmental health. However, while it has already eclipsed solution protein chemistry as a discipline, it is still essentially an extension of classical protein chemistry, owing much of its maturation to prior contributions. Unfortunately, this debt is not always evident in current literature.

The Evolution from Protein Chemistry to Proteomics: Basic Science to Clinical Application, in providing a different perspective than other reviews, strengthens the connection between solution protein chemistry and proteomic technology. Towards this end, Roger Lundblad, a long-time leader in protein chemistry and a scientist who has worked in both academics and industry, brings together some seemingly disparate areas into a single volume. Discussing analytical proteomics, expression proteomics, and clinical proteomics (biomarker identification), he provides coverage that is uniquely rich in detail.

Lundblad applies this detail to sample preparation for proteomic analysis, including preparation from blood and tissues. He also presents specifics on the prefractionation of samples used to identify specific subproteomes such as phosphoproteomes and glycoproteomes. Comprehensive reviews are provided covering the chemical modification of proteins, including its use for chemical proteomics. Special attention is given to challenges that impede the identification, validation, and development of biomarkers into clinically useful diagnostic analytes.

A bestselling author, Lundblad utilizes classical protein chemistry literature in providing an intellectual basis for proteomics that merges current concepts with the existing literature, while providing the technical detail necessary for the effective commercialization of proteomics.

About the Author

Roger L. Lundblad