Title: Experimental Studies on Diphtheric Immunity: A Dissertation Submitted to the Faculty of the Ogden Graduate School of Science in Candidacy for the Degree of Doctor of Philosophy (Department of Bacteriology) (Classic Reprint)
Publisher: Forgotten Books
Publication Date: 2018
Language: English
ISBN 10: 0265917042
ISBN 13: 9780265917046
Binding: HRD
Condition: New
Weight: 289 grams

About this title

Synopsis

How diphtheria toxin affects different animals and what that reveals about immunity

This study presents a detailed look at how diphtheria toxin acts in white rats, rabbits, and guinea pigs. It reports on lethal doses, tissue reactions, and the surprising ways some animals resist or succumb to exposure, shedding light on immune responses and protection methods.

In these experiments, the author compares routes of toxin delivery, observes age-related differences in susceptibility, and investigates the limits of artificial immunity. The work also examines how antitoxin behaves in the body and why immunization can produce not only protection but occasional hypersensitivity in certain animals.

Minimum lethal doses for different species and how they change with age and route of administration
Physical and chemical responses in tissue and blood that accompany exposure
Experiments on immunization attempts in rabbits and the surprising risk of hypersusceptibility
Insights into antitoxin behavior, storage, and its role in immunity

Ideal for readers of early 20th‑century toxin studies, immunology, and vaccine research, especially those interested in the mechanisms of diphtheria immunity and animal models.

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